Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALKBH1 | Q13686 | 2/20 | 0.42 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27817858 | 0.83 | ALDH1A1 (0.43) | MRGPRX4ALDH1A1LMNAHTTRAB9A | |
| SCHEMBL27911849 | 0.83 | ALDH1A1 (0.43) | MRGPRX4ALDH1A1HTTNPSR1PLA2G2D | |
| SCHEMBL27660886 | 0.79 | EPHX2 (0.48) | MRGPRX4ALDH1A1HTTNPSR1PLA2G2D | |
| SCHEMBL27527292 | 0.78 | MRGPRX4 (0.48) | MRGPRX4ALDH1A1LMNAMAPK1HTT | |
| SCHEMBL3684044 | 0.75 | MRGPRX4 (0.51) | MRGPRX4ALDH1A1LMNAMAPK1HTT | |
| SCHEMBL29759273 | 0.75 | MRGPRX4 (0.51) | MRGPRX4ALDH1A1LMNAMAPK1HTT | |
| SCHEMBL1401550 | 0.75 | MRGPRX4 (0.55) | MRGPRX4LMNAMAPK1HTTRAB9A | |
| SCHEMBL31385498 | 0.75 | MRGPRX4 (0.52) | MRGPRX4LMNAMAPK1HTTRAB9A | |
| SCHEMBL23978049 | 0.75 | MRGPRX4 (0.52) | MRGPRX4LMNAMAPK1HTTRAB9A | |
| SCHEMBL4259943 | 0.74 | MRGPRX4 (0.50) | MRGPRX4ALDH1A1LMNAMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023288253-A1 | SMALL MOLECULES INHIBITORS OF CYCLIC GMP-AMP SYNTHASE (CGAS) | THE SCRIPPS RESEARCH INSTITUTE (US) | 2023-01-19 | — | — | WO | disclosed |