Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.35 |
| ▸ | GRN | P28799 | 1/20 | 0.34 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 2/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.31 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27830838 | 1.00 | HCAR1 (0.35) | HCAR1GRNSORT1CTSLCA12 | |
| SCHEMBL2503184 | 1.00 | HCAR1 (0.35) | HCAR1GRNSORT1CTSLCA12 | |
| SCHEMBL2503341 | 0.81 | HCAR1 (0.40) | HCAR1CA12CA1CA9FOLH1 | |
| SCHEMBL2503237 | 0.81 | HCAR1 (0.40) | HCAR1CA12CA1CA9FOLH1 | |
| SCHEMBL2499342 | 0.79 | FFAR1 (0.43) | FFAR1 | |
| SCHEMBL2505238 | 0.79 | FFAR1 (0.43) | FFAR1 | |
| SCHEMBL3659553 | 0.75 | HCAR1 (0.37) | HCAR1GRNSORT1CTSLCA12 | |
| SCHEMBL3653714 | 0.75 | HCAR1 (0.37) | HCAR1GRNSORT1CTSLCA12 | |
| SCHEMBL2503179 | 0.73 | HCAR1 (0.35) | HCAR1CA12CA1CA9FFAR1 | |
| SCHEMBL2495823 | 0.73 | HCAR1 (0.35) | HCAR1CA12CA1CA9FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8030354-B2 | 2-(5,5-Dimethylcyclopent-1-enyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; metabolic disorders such as type II diabetes | AMGEN INC. (US) | 2011-10-04 | — | — | US | disclosed |
| CN-102083783-A | Substituted biphenyl GPR40 modulators | AMGEN INC | 2011-06-01 | — | — | CN | disclosed |