Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | BUB1 | O43683 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PREP | P48147 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28704785 | 1.00 | CYP3A4 (0.60) | CYP3A4MAPK1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL30577854 | 0.84 | MAPK1 (0.54) | CYP3A4MAPK1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL29118910 | 0.77 | CYP3A4 (0.75) | CYP3A4MAPK1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL2873400 | 0.77 | CYP3A4 (0.75) | CYP3A4MAPK1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL2494815 | 0.76 | PREP (0.39) | CYP3A4MAPK1SMN1; SMN2BUB1PREP | |
| SCHEMBL30577846 | 0.76 | MAPK1 (0.38) | CYP3A4MAPK1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL4057796 | 0.76 | MAPK1 (0.43) | CYP3A4MAPK1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL3390628 | 0.74 | PREP (0.37) | CYP3A4MAPK1SMN1; SMN2BUB1PREP | |
| SCHEMBL6188259 | 0.70 | USP2 (0.38) | SMN1; SMN2HPGDBUB1PREPCTSK | |
| SCHEMBL16594444 | 0.70 | USP2 (0.38) | SMN1; SMN2HPGDBUB1PREPCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8030499-B2 | 1,3-dihydro-2H-indole-2-one compound and pyrrolidine-2-one compound fused with aromatic heterocycle | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2011-10-04 | — | — | US | disclosed |