Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
| ▸ | BUB1 | O43683 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3390628 | 0.85 | PREP (0.37) | PREPCYP3A4MAPK1GPR119BUB1 | |
| SCHEMBL25870113 | 0.78 | PREP (0.38) | PREPMAPK1BUB1CTSKUSP2 | |
| SCHEMBL6188259 | 0.76 | USP2 (0.38) | PREPGPR119BUB1CTSKUSP2 | |
| SCHEMBL16594444 | 0.76 | USP2 (0.38) | PREPGPR119BUB1CTSKUSP2 | |
| SCHEMBL28704785 | 0.76 | CYP3A4 (0.60) | PREPCYP3A4MAPK1BUB1CTSK | |
| SCHEMBL2495889 | 0.76 | CYP3A4 (0.60) | PREPCYP3A4MAPK1BUB1CTSK | |
| SCHEMBL2494601 | 0.76 | GPR119 (0.34) | PREPGPR119BUB1USP2SMN1; SMN2 | |
| SCHEMBL7470295 | 0.74 | NR1H2 (0.34) | PREPNR1H2NR1H3RORC | |
| SCHEMBL7227763 | 0.73 | USP2 (0.40) | PREPGPR119BUB1CTSKUSP2 | |
| SCHEMBL4249117 | 0.73 | USP2 (0.40) | PREPGPR119BUB1CTSKUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2370426-A1 | N-{[(IR,4S,6R-3-(2-PYRIDINYLCARBONYL)-3-AZABICYCLO [4.1.0]HEPT-4-YL]METHYL}-2-HETEROARYLAMINE DERIVATIVES AND USES THEREOF | Glaxo Group Limited (GB) | 2011-10-05 | — | — | EP | disclosed |