Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | RET | P07949 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.55 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.52 |
| ▸ | PAK4 | O96013 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | CTRC | Q99895 | 1/20 | 0.49 |
| ▸ | ROS1 | P08922 | 1/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.49 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5999570 | 0.84 | PDPK1 (0.65) | PDPK1RETNTRK1PDGFRBPAK4 | |
| SCHEMBL3747231 | 0.84 | NTRK1 (0.65) | PDPK1KMT2AMEN1RETMAPT | |
| SCHEMBL5358233 | 0.84 | PDPK1 (0.62) | PDPK1KMT2AMEN1RETMAPT | |
| SCHEMBL18499300 | 0.84 | PDPK1 (0.62) | PDPK1KMT2ARETALDH1A1NTRK1 | |
| SCHEMBL3749915 | 0.84 | PDPK1 (0.62) | PDPK1KMT2AMEN1RETMAPT | |
| SCHEMBL29638268 | 0.84 | NTRK1 (0.65) | PDPK1KMT2AMEN1RETMAPT | |
| SCHEMBL5999571 | 0.84 | PDPK1 (0.65) | PDPK1RETNTRK1PDGFRBPAK4 | |
| SCHEMBL3749912 | 0.84 | PDPK1 (0.62) | PDPK1KMT2AMEN1RETMAPT | |
| SCHEMBL3747230 | 0.84 | NTRK1 (0.65) | PDPK1KMT2AMEN1RETMAPT | |
| SCHEMBL17679355 | 0.81 | PDPK1 (0.74) | PDPK1KMT2AMEN1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023001942-A1 | 14-3-3 PROTEIN MODULATORS AS ANTITUMOR AGENTS | RAPPOSELLI SIMONA (IT) | 2023-01-26 | — | — | WO | disclosed |