Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.62 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | RAF1 | P04049 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | APP | P05067 | 2/20 | 0.53 |
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.53 |
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | ARAF | P10398 | 1/20 | 0.53 |
| ▸ | PIM1 | P11309 | 1/20 | 0.53 |
| ▸ | BRAF | P15056 | 1/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.53 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5999570 | 0.84 | PDPK1 (0.65) | PDPK1NTRK1PAK4RETTGM2 | |
| SCHEMBL29638268 | 0.84 | NTRK1 (0.65) | PDPK1NTRK1MAPTKMT2AEGFR | |
| SCHEMBL18499300 | 0.84 | PDPK1 (0.62) | PDPK1NTRK1HPGDKMT2AHTT | |
| SCHEMBL3747231 | 0.84 | NTRK1 (0.65) | PDPK1NTRK1MAPTKMT2AEGFR | |
| SCHEMBL3749915 | 0.84 | PDPK1 (0.62) | PDPK1NTRK1MAPTKMT2AMAP1LC3B | |
| SCHEMBL24967152 | 0.84 | PDPK1 (0.65) | PDPK1NTRK1MAPTHPGDKMT2A | |
| SCHEMBL5999571 | 0.84 | PDPK1 (0.65) | PDPK1NTRK1PAK4RETTGM2 | |
| SCHEMBL3749912 | 0.84 | PDPK1 (0.62) | PDPK1NTRK1MAPTKMT2AMAP1LC3B | |
| SCHEMBL3747230 | 0.84 | NTRK1 (0.65) | PDPK1NTRK1MAPTKMT2AEGFR | |
| SCHEMBL3754999 | 0.81 | KDR (0.69) | PDPK1NTRK1MAPTHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | PDPK1 31/4885NTRK1 223/4885MAPT 3048/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.