SCHEMBL24969832

SCHEMBL24969832

CC(C)(C)OC(=O)c1ccn(C(=O)N2CC3CC(OCc4ccccc4Cl)CC3C2)n1

nearest known ligand 0.77

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 13/20 0.77
FAAH O00519 6/20 0.77
MEN1 O00255 1/20 0.39
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39
KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20920378 1.00 MGLL (0.77) MGLLFAAHMEN1NPC1RAB9A
SCHEMBL22986970 0.90 MGLL (0.62) MGLLFAAH
SCHEMBL20567339 0.90 MGLL (0.62) MGLLFAAH
SCHEMBL24970334 0.90 MGLL (0.62) MGLLFAAH
SCHEMBL30302140 0.90 MGLL (0.62) MGLLFAAH
SCHEMBL25829837 0.88 MGLL (0.84) MGLLFAAH
SCHEMBL25829895 0.88 MGLL (0.84) MGLLFAAH
SCHEMBL24969914 0.87 MGLL (1.00) MGLLFAAH
SCHEMBL20920370 0.87 MGLL (1.00) MGLLFAAH
SCHEMBL20920412 0.87 MGLL (1.00) MGLLFAAH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116473965-B Pyrazole MAGL inhibitors H.隆德贝克有限公司 2025-03-18 CN disclosed
CN-116473965-A Pyrazole MAGL inhibitors H.隆德贝克有限公司 2023-07-25 CN disclosed
EP-4198024-A1 PYRAZOLE MAGL INHIBITORS H. Lundbeck A/S (DK) 2023-06-21 EP disclosed
CN-110678456-B Pyrazole MAGL inhibitors H.隆德贝克有限公司 2023-05-02 CN disclosed
EP-3630744-B1 PYRAZOLE MAGL INHIBITORS H LUNDBECK AS (DK) 2023-01-25 EP disclosed