Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 1/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.33 |
| ▸ | PARG | Q86W56 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | KDM4A | O75164 | 1/20 | 0.32 |
| ▸ | KDM5C | P41229 | 1/20 | 0.32 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL21491582 | 0.81 | GABRA1 (0.42) | KLKB1ENPP2NPC1RAB9AHRH4 | |
| SCHEMBL15721483 | 0.79 | GABRA1 (0.46) | KLKB1ENPP2PARGNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL21491661 | 0.78 | GABRA1 (0.37) | PARGGABRA1GABRR1GABRA3GABRA2 | |
| SCHEMBL24493320 | 0.74 | HDAC1 (0.43) | ENPP2HRH4GABRA1GABRR1GABRA3 | |
| SCHEMBL24973972 | 0.72 | GABRA1 (0.37) | PKMGABRA1GABRR1GABRA3GABRA2 | |
| Hydrochloric Acid SCHEMBL21491926 | 0.72 | GABRA1 (0.39) | HRH4PKMGABRA1GABRR1GABRA3 | |
| SCHEMBL25727726 | 0.70 | NPC1 (0.36) | KLKB1ENPP2PARGNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL21491630 | 0.70 | GABRA1 (0.40) | HRH4GABRA1GABRR1GABRA3GABRA2 | |
| Hydrochloric Acid SCHEMBL21491681 | 0.69 | GABRA1 (0.39) | GABRA1GABRR1GABRA3GABRA2GABRB2 | |
| SCHEMBL4192158 | 0.69 | KLKB1 (0.48) | KLKB1ENPP2NPC1RAB9AHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11572364-B2 | Pteridinone compounds and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11572364-B2 | Pteridinone compounds and uses thereof | DPYD, PKD1, TYMP | KLKB1 630/4885ENPP2 2289/4885PARG 614/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.