Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 5/20 | 0.38 |
| ▸ | AVPR1B | P47901 | 5/20 | 0.38 |
| ▸ | OXTR | P30559 | 4/20 | 0.38 |
| ▸ | AVPR2 | P30518 | 3/20 | 0.38 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.31 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2494027 | 0.87 | AVPR1A (0.44) | AVPR1AAVPR1BOXTRAVPR2GPR65 | |
| SCHEMBL2495051 | 0.87 | AVPR1A (0.42) | AVPR1AAVPR1BOXTRAVPR2GPR65 | |
| SCHEMBL2495336 | 0.85 | BRD4 (0.41) | AVPR1AAVPR1BOXTRAVPR2GPR65 | |
| SCHEMBL2498353 | 0.84 | BRD4 (0.39) | AVPR1AAVPR1BOXTRAVPR2GPR65 | |
| SCHEMBL2496752 | 0.84 | L3MBTL1 (0.39) | AVPR1AAVPR1BOXTRAVPR2GPR65 | |
| SCHEMBL2493428 | 0.82 | BRD4 (0.38) | AVPR1AAVPR1BOXTRAVPR2GPR65 | |
| SCHEMBL2498096 | 0.81 | BRD4 (0.37) | AVPR1AAVPR1BOXTRAVPR2GPR65 | |
| SCHEMBL2496940 | 0.80 | BRD4 (0.38) | AVPR1AAVPR1BOXTRAVPR2GPR65 | |
| SCHEMBL2497606 | 0.78 | AVPR1A (0.36) | AVPR1AAVPR1BOXTRAVPR2GPR65 | |
| SCHEMBL5353210 | 0.77 | AVPR1A (0.43) | AVPR1AAVPR1BOXTRAVPR2GPR65 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8030499-B2 | 1,3-dihydro-2H-indole-2-one compound and pyrrolidine-2-one compound fused with aromatic heterocycle | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2011-10-04 | — | — | US | disclosed |
| US-20080318923-A1 | 1,3-Dihydro-2H-Indole-2-One Compound and Pyrrolidine-2-One Compound Fused With Aromatic Heterocycle | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318923-A1 | 1,3-Dihydro-2H-Indole-2-One Compound and Pyrrolidine-2-One Compound Fused With Aromatic Heterocycle | AVPR1B, AVPR1A, AVPR2 | AVPR1A 2/4885AVPR1B 1/4885OXTR 37/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.