Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 9/20 | 0.49 |
| ▸ | KDR | P35968 | 11/20 | 0.40 |
| ▸ | CSF1R | P07333 | 8/20 | 0.40 |
| ▸ | KIT | P10721 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.36 |
| ▸ | CLK2 | P49760 | 2/20 | 0.36 |
| ▸ | CLK3 | P49761 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24975939 | 0.92 | FLT3 (0.45) | FLT3KDRCSF1RKITCYP2D6 | |
| SCHEMBL24231241 | 0.89 | FLT3 (0.60) | FLT3KDRCSF1RKITCYP2D6 | |
| SCHEMBL25989836 | 0.89 | FLT3 (0.60) | FLT3KDRCSF1RKITCYP2D6 | |
| SCHEMBL24975661 | 0.89 | FLT3 (0.50) | FLT3KDRCSF1RKITCYP2D6 | |
| SCHEMBL24975663 | 0.88 | FLT3 (0.62) | FLT3KDRCSF1RKITCYP2D6 | |
| SCHEMBL24231493 | 0.86 | FLT3 (0.52) | FLT3KDRCSF1RKITCYP2D6 | |
| SCHEMBL24975667 | 0.86 | FLT3 (0.45) | FLT3KDRCSF1RKITCYP2D6 | |
| SCHEMBL31557793 | 0.86 | FLT3 (0.45) | FLT3KDRCSF1RKITCYP2D6 | |
| SCHEMBL24975664 | 0.85 | FLT3 (0.50) | FLT3KDRCSF1RKITCYP2D6 | |
| SCHEMBL24975937 | 0.83 | IRAK4 (0.51) | FLT3KDRCSF1RKITCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023009833-A9 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-11-23 | — | — | WO | disclosed |
| WO-2023009833-A1 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-02-02 | — | — | WO | disclosed |