Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 7/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.41 |
| ▸ | JUN | P05412 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | IDH1 | O75874 | 1/20 | 0.41 |
| ▸ | CCNK | O75909 | 3/20 | 0.40 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | EIF2AK4 | Q9P2K8 | 2/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24975718 | 1.00 | MAPK9 (0.42) | MAPK9TRPV1MAPK8MAPK10JUN | |
| SCHEMBL30248414 | 1.00 | MAPK9 (0.42) | MAPK9TRPV1MAPK8MAPK10JUN | |
| SCHEMBL26661914 | 0.91 | MAPK9 (0.44) | MAPK9MAPK8MAPK10JUNCDK2 | |
| SCHEMBL31000078 | 0.90 | EIF2AK4 (0.46) | MAPK9TRPV1MAPK8MAPK10JUN | |
| SCHEMBL31000111 | 0.87 | CDK4 (0.40) | MAPK9TRPV1MAPK8MAPK10JUN | |
| SCHEMBL24977595 | 0.87 | HDAC4 (0.38) | TRPV1IDH1USP30HDAC4HDAC6 | |
| SCHEMBL24977598 | 0.87 | HDAC4 (0.38) | TRPV1IDH1USP30HDAC4HDAC6 | |
| SCHEMBL31068084 | 0.86 | SYK (0.38) | TRPV1IDH1USP30HDAC4HDAC6 | |
| SCHEMBL24574149 | 0.85 | FLT3 (0.48) | IDH1IRAK4USP30EIF2AK4BTK | |
| SCHEMBL24976078 | 0.83 | MAPK9 (0.43) | MAPK9MAPK8MAPK10JUNCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023009833-A9 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-11-23 | — | — | WO | disclosed |
| WO-2023009833-A1 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-02-02 | — | — | WO | disclosed |