Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK4 | Q9P2K8 | 13/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.42 |
| ▸ | JUN | P05412 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | CCNK | O75909 | 1/20 | 0.39 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24975716 | 0.90 | MAPK9 (0.42) | EIF2AK4TRPV1MAPK9MAPK10MAPK8 | |
| SCHEMBL30248414 | 0.90 | MAPK9 (0.42) | EIF2AK4TRPV1MAPK9MAPK10MAPK8 | |
| SCHEMBL24975718 | 0.90 | MAPK9 (0.42) | EIF2AK4TRPV1MAPK9MAPK10MAPK8 | |
| SCHEMBL25998064 | 0.88 | EIF2AK4 (0.44) | EIF2AK4TRPV1HDAC4HDAC6 | |
| SCHEMBL31000122 | 0.87 | EIF2AK4 (0.43) | EIF2AK4TRPV1HDAC4HDAC6 | |
| SCHEMBL24976078 | 0.82 | MAPK9 (0.43) | MAPK9MAPK10MAPK8JUNCDK2 | |
| SCHEMBL24231691 | 0.81 | SYK (0.43) | EIF2AK4HDAC4HDAC6 | |
| SCHEMBL26661914 | 0.81 | MAPK9 (0.44) | EIF2AK4MAPK9MAPK10MAPK8JUN | |
| SCHEMBL31000113 | 0.80 | IRAK4 (0.51) | EIF2AK4MAPK9MAPK10MAPK8JUN | |
| SCHEMBL25338902 | 0.78 | EIF2AK4 (0.43) | EIF2AK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4658659-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | Children's Hospital Medical Center (US) | 2025-12-10 | — | — | EP | disclosed |
| WO-2024163764-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2024-08-08 | — | — | WO | disclosed |