Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | BTK | Q06187 | 2/20 | 0.38 |
| ▸ | NRAS | P01111 | 3/20 | 0.38 |
| ▸ | FLT3 | P36888 | 3/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | CDK7 | P50613 | 1/20 | 0.36 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.36 |
| ▸ | CCNH | P51946 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24976599 | 1.00 | SYK (0.39) | SYKPIK3CDEHMT2EGFRBTK | |
| SCHEMBL24231884 | 0.91 | FLT3 (0.49) | NRASFLT3USP30LCKRET | |
| SCHEMBL24976078 | 0.87 | MAPK9 (0.43) | SYKPIK3CDEHMT2EGFRUSP30 | |
| SCHEMBL30248534 | 0.87 | USP30 (0.36) | EHMT2EGFRNRASFLT3RIPK1 | |
| SCHEMBL26661903 | 0.87 | USP30 (0.36) | EHMT2EGFRNRASFLT3RIPK1 | |
| SCHEMBL24975903 | 0.87 | USP30 (0.36) | EHMT2EGFRNRASFLT3RIPK1 | |
| SCHEMBL24231497 | 0.83 | FLT3 (0.51) | NRASFLT3USP30LCKRET | |
| SCHEMBL24975705 | 0.83 | EHMT2 (0.38) | SYKPIK3CDEHMT2EGFRBTK | |
| SCHEMBL24977595 | 0.81 | HDAC4 (0.38) | SYKEGFRBTKFLT3USP30 | |
| SCHEMBL24977598 | 0.81 | HDAC4 (0.38) | SYKEGFRBTKFLT3USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023009833-A9 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-11-23 | — | — | WO | disclosed |
| WO-2023009833-A1 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-02-02 | — | — | WO | disclosed |