Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 15/20 | 0.53 |
| ▸ | IRAK4 | Q9NWZ3 | 10/20 | 0.53 |
| ▸ | IRAK1 | P51617 | 6/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.53 |
| ▸ | CDK7 | P50613 | 4/20 | 0.53 |
| ▸ | CCNH | P51946 | 4/20 | 0.53 |
| ▸ | LCK | P06239 | 2/20 | 0.53 |
| ▸ | RET | P07949 | 2/20 | 0.53 |
| ▸ | BLK | P51451 | 1/20 | 0.53 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.53 |
| ▸ | NRAS | P01111 | 9/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.40 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10239502 | 0.85 | FLT3 (0.57) | FLT3IRAK4IRAK1PDGFRBCDK7 | |
| SCHEMBL24977165 | 0.84 | IRAK4 (0.52) | FLT3IRAK4IRAK1PDGFRBCDK7 | |
| SCHEMBL10238505 | 0.82 | FLT3 (0.58) | FLT3IRAK4IRAK1PDGFRBCDK7 | |
| SCHEMBL24975679 | 0.80 | FLT3 (0.50) | FLT3IRAK4IRAK1PDGFRBCDK7 | |
| SCHEMBL24976224 | 0.80 | FLT3 (0.50) | FLT3IRAK4IRAK1PDGFRBCDK7 | |
| SCHEMBL30248355 | 0.80 | FLT3 (0.50) | FLT3IRAK4IRAK1PDGFRBCDK7 | |
| SCHEMBL376686 | 0.79 | IRAK4 (0.59) | FLT3IRAK4IRAK1PDGFRBCDK7 | |
| SCHEMBL10239817 | 0.79 | FLT3 (0.61) | FLT3IRAK4IRAK1PDGFRBCDK7 | |
| SCHEMBL10239509 | 0.79 | FLT3 (0.61) | FLT3IRAK4IRAK1PDGFRBCDK7 | |
| SCHEMBL376738 | 0.79 | FLT3 (0.79) | FLT3IRAK4IRAK1PDGFRBCDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023009833-A1 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-02-02 | — | — | WO | disclosed |