Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 2/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2498866 | 1.00 | OPRD1 (0.46) | OPRD1OPRK1FFAR1SLC6A3MEN1 | |
| SCHEMBL15972566 | 1.00 | OPRD1 (0.46) | OPRD1OPRK1FFAR1SLC6A3MEN1 | |
| SCHEMBL2495215 | 0.95 | OPRD1 (0.48) | OPRD1OPRK1FFAR1SLC6A3HIF1A | |
| SCHEMBL30533375 | 0.95 | OPRD1 (0.48) | OPRD1OPRK1FFAR1SLC6A3HIF1A | |
| SCHEMBL29454583 | 0.95 | OPRD1 (0.48) | OPRD1OPRK1FFAR1SLC6A3HIF1A | |
| SCHEMBL2504416 | 0.95 | OPRD1 (0.48) | OPRD1OPRK1FFAR1SLC6A3HIF1A | |
| SCHEMBL2501419 | 0.95 | OPRD1 (0.48) | OPRD1OPRK1FFAR1SLC6A3HIF1A | |
| SCHEMBL29454615 | 0.95 | OPRD1 (0.48) | OPRD1OPRK1FFAR1SLC6A3HIF1A | |
| SCHEMBL12193231 | 0.87 | OPRD1 (0.42) | OPRD1OPRK1FFAR1SLC6A3SLC6A4 | |
| SCHEMBL12193233 | 0.87 | OPRD1 (0.42) | OPRD1OPRK1FFAR1SLC6A3SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8030354-B2 | 2-(5,5-Dimethylcyclopent-1-enyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; metabolic disorders such as type II diabetes | AMGEN INC. (US) | 2011-10-04 | — | — | US | disclosed |
| CN-102083783-A | Substituted biphenyl GPR40 modulators | AMGEN INC | 2011-06-01 | — | — | CN | disclosed |