Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 7/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24977875 | 0.83 | CYP4F2 (0.36) | CYP4F2CYP4A11 | |
| SCHEMBL22826421 | 0.82 | CYP4F2 (0.38) | RAB9AFAAHALDH1A1KMT2ACYP4F2 | |
| SCHEMBL6502231 | 0.79 | CYP4F2 (0.39) | RAB9AFAAHALDH1A1KMT2ACYP4F2 | |
| SCHEMBL6501940 | 0.78 | CYP4F2 (0.38) | L3MBTL1RAB9AFAAHALDH1A1MEN1 | |
| SCHEMBL6502716 | 0.74 | KMT2A (0.42) | RAB9AFAAHALDH1A1KMT2ACYP4F2 | |
| SCHEMBL20382691 | 0.72 | SMYD3 (0.38) | TDP1ALDH1A1MEN1KMT2ACYP4F2 | |
| SCHEMBL31461709 | 0.72 | TDP1 (0.42) | TDP1L3MBTL1RAB9AFAAHALDH1A1 | |
| SCHEMBL26638900 | 0.72 | CYP4F2 (0.46) | RAB9AALDH1A1CYP4F2CYP4A11LMNA | |
| SCHEMBL24977890 | 0.71 | CYP4F2 (0.35) | CYP4F2CYP4A11 | |
| SCHEMBL31461686 | 0.70 | ATR (0.43) | TDP1L3MBTL1RAB9AFAAHALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230021562-A1 | MACROCYLIC INDOLE DERIVATIVES MCL-1 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230021562-A1 | MACROCYLIC INDOLE DERIVATIVES MCL-1 INHIBITORS | MCL1, BCL2L1, BAK1 | TDP1 924/4885L3MBTL1 362/4885RAB9A 4200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.