Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 18/20 | 0.79 |
| ▸ | DDX5 | P17844 | 1/20 | 0.79 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | HBB | P68871 | 2/20 | 0.58 |
| ▸ | CASP1 | P29466 | 1/20 | 0.58 |
| ▸ | CASP7 | P55210 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | GLA | P06280 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | STAT6 | P42226 | 1/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.57 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.57 |
| ▸ | GMNN | O75496 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30255916 | 0.88 | TOP1 (1.00) | TOP1DDX5MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL29429769 | 0.88 | TOP1 (1.00) | TOP1DDX5MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL20286453 | 0.88 | TOP1 (1.00) | TOP1DDX5MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL18296600 | 0.88 | TOP1 (1.00) | TOP1DDX5MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9563404 | 0.88 | TOP1 (1.00) | TOP1DDX5MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL29473358 | 0.88 | TOP1 (1.00) | TOP1DDX5MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL27407822 | 0.86 | TOP1 (0.78) | TOP1DDX5MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL25129440 | 0.85 | TOP1 (0.77) | TOP1DDX5MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL25129742 | 0.85 | TOP1 (0.77) | TOP1DDX5MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8194838 | 0.85 | TOP1 (0.78) | TOP1MEN1KMT2ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230036256-A1 | CAMPTOTHECIN CONJUGATES | SEAGEN INC. | 2023-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230036256-A1 | CAMPTOTHECIN CONJUGATES | DCLRE1A, TOP2A, PAICS | TOP1 4/4885DDX5 2703/4885MEN1 636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.