Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2500874 | 1.00 | HCRTR1 (0.57) | HCRTR1HCRTR2 | |
| SCHEMBL2503733 | 0.89 | HCRTR1 (0.71) | HCRTR1HCRTR2 | |
| SCHEMBL2497343 | 0.89 | HCRTR1 (0.71) | HCRTR1HCRTR2 | |
| SCHEMBL2501610 | 0.88 | HCRTR1 (0.60) | HCRTR1HCRTR2 | |
| SCHEMBL2503110 | 0.88 | HCRTR1 (0.60) | HCRTR1HCRTR2 | |
| SCHEMBL21018765 | 0.88 | HCRTR1 (0.60) | HCRTR1HCRTR2 | |
| SCHEMBL8167758 | 0.85 | HCRTR1 (0.73) | HCRTR1HCRTR2 | |
| SCHEMBL2519128 | 0.84 | HCRTR1 (0.72) | HCRTR1HCRTR2 | |
| SCHEMBL2502208 | 0.84 | HCRTR1 (0.72) | HCRTR1HCRTR2 | |
| SCHEMBL2495394 | 0.79 | HCRTR1 (0.61) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150115-B1 | CYCLOPROPYL PYRROLIDINE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2013-09-18 | — | — | EP | claimed |
| US-8030495-B2 | Cyclopropyl pyrrolidine orexin receptor antagonists | MERCK SHARP & DOHME CORP. | 2011-10-04 | — | — | US | claimed |
| EP-2150115-A1 | CYCLOPROPYL PYRROLIDINE OREXIN RECEPTOR ANTAGONISTS | Merck and Co., Inc. (US) | 2010-02-10 | — | — | EP | claimed |
| WO-2008150364-A1 | CYCLOPROPYL PYRROLIDINE OREXIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2008-12-11 | — | — | WO | claimed |
| EP-2150115-B1 | CYCLOPROPYL PYRROLIDINE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2013-09-18 | — | — | EP | disclosed |