Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOST | Q9BQB4 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.32 |
| ▸ | NQO2 | P16083 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | DDX3X | O00571 | 1/20 | 0.31 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.31 |
| ▸ | OGFRL1 | Q5TC84 | 2/20 | 0.31 |
| ▸ | HTR2A | P28223 | 3/20 | 0.31 |
| ▸ | HTR2C | P28335 | 3/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL186101 | 0.78 | PTGDR2 (0.47) | — | |
| SCHEMBL234225 | 0.62 | HTR2A (0.43) | HTR2AHTR2C | |
| SCHEMBL13448722 | 0.58 | HTR2A (0.42) | HTR2AHTR2C | |
| SCHEMBL233436 | 0.58 | HTR2A (0.47) | POLBHTR2AHTR2C | |
| SCHEMBL231854 | 0.58 | HTR2A (0.51) | HTR2AHTR2C | |
| SCHEMBL21027979 | 0.58 | HTR2A (0.43) | HTTHTR2AHTR2C | |
| SCHEMBL476641 | 0.57 | MEN1 (0.61) | HTTPOLB | |
| SCHEMBL20920608 | 0.57 | MIF (0.49) | — | |
| SCHEMBL8447696 | 0.57 | HTR2A (0.43) | HTR2AHTR2C | |
| SCHEMBL13279281 | 0.57 | HTR2A (0.40) | OPRM1OPRK1HTR4OGFRL1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401269-A1 | INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS | Merck Sharp & Dohme Corp. (US) | 2012-01-04 | — | — | EP | disclosed |