Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 10/20 | 0.43 |
| ▸ | CTSC | P53634 | 5/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30738929 | 0.86 | CTSC (0.46) | KCNJ1CTSCGPR55CTSKSCD5 | |
| SCHEMBL24981577 | 0.86 | KCNJ1 (0.51) | KCNJ1CTSCGPR55SCD5 | |
| SCHEMBL24981584 | 0.83 | KCNJ1 (0.45) | KCNJ1CTSCGPR55SCD5ALDH1A1 | |
| SCHEMBL24981827 | 0.82 | KCNJ1 (0.43) | KCNJ1CTSCGPR55SCD5ALDH1A1 | |
| SCHEMBL24982010 | 0.82 | KCNJ1 (0.46) | KCNJ1CTSCGPR55CTSK | |
| SCHEMBL29455649 | 0.81 | KCNJ1 (0.39) | KCNJ1CTSCGPR55SCD5ALDH1A1 | |
| SCHEMBL25146985 | 0.81 | KCNJ1 (0.39) | KCNJ1CTSCGPR55SCD5ALDH1A1 | |
| SCHEMBL30738908 | 0.81 | CTSC (0.41) | KCNJ1CTSCGPR55CTSKSCD5 | |
| SCHEMBL24982006 | 0.80 | CTSC (0.40) | KCNJ1CTSCGPR55CTSKSCD5 | |
| SCHEMBL31095717 | 0.78 | CTSC (0.43) | KCNJ1CTSCCTSKSCD5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11807635-B2 | Nitrile derivative that acts as inhibitor of dipeptidyl peptidase 1 and use thereof | HAISCO PHARMACEUTICALS PTE. LTD. (SG) | 2023-11-07 | — | — | US | disclosed |
| US-11807635-B2 | Nitrile derivative that acts as inhibitor of dipeptidyl peptidase 1 and use thereof | HAISCO PHARMACEUTICALS PTE. LTD. (SG) | 2023-11-07 | — | — | US | disclosed |
| CN-115996923-A | Nitrile derivative as dipeptidyl peptidase 1 inhibitor and application thereof | 四川海思科制药有限公司 | 2023-04-21 | — | — | CN | disclosed |
| US-20230121807-A1 | NITRILE DERIVATIVE THAT ACTS AS INHIBITOR OF DIPEPTIDYL PEPTIDASE 1 AND USE THEREOF | HAISCO PHARMACEUTICALS PTE. LTD (SG) | 2023-04-20 | — | — | US | disclosed |
| EP-4129989-A1 | NITRILE DERIVATIVE THAT ACTS AS INHIBITOR OF DIPEPTIDYL PEPTIDASE 1 AND USE THEREOF | Haisco Pharmaceuticals Pte. Ltd. (SG) | 2023-02-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11807635-B2 | Nitrile derivative that acts as inhibitor of dipeptidyl peptidase 1 and use thereof | DPP4, DPP3, DPP9 | KCNJ1 3424/4885CTSC 4/4885GPR55 4171/4885 |
| US-20230121807-A1 | NITRILE DERIVATIVE THAT ACTS AS INHIBITOR OF DIPEPTIDYL PEPTIDASE 1 AND USE THEREOF | DPP4, DPP3, DPP9 | KCNJ1 3424/4885CTSC 4/4885GPR55 4171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.