Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 16/20 | 0.60 |
| ▸ | DRD4 | P21917 | 11/20 | 0.60 |
| ▸ | DRD2 | P14416 | 4/20 | 0.54 |
| ▸ | DRD3 | P35462 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31185375 | 1.00 | GRM2 (0.60) | GRM2DRD4DRD2DRD3KDM4E | |
| SCHEMBL31185393 | 0.88 | GRM2 (0.54) | GRM2DRD4DRD2DRD3KDM4E | |
| SCHEMBL31185404 | 0.86 | GRM2 (0.62) | GRM2DRD4DRD2DRD3KDM4E | |
| SCHEMBL24984229 | 0.86 | GRM2 (0.62) | GRM2DRD4DRD2DRD3KDM4E | |
| SCHEMBL24984224 | 0.85 | LMNA (0.60) | GRM2DRD4DRD2DRD3KDM4E | |
| SCHEMBL24984211 | 0.85 | GRM2 (0.52) | GRM2DRD4KDM4EOPRM1OPRD1 | |
| SCHEMBL31185410 | 0.85 | GRM2 (0.52) | GRM2DRD4KDM4EOPRM1OPRD1 | |
| SCHEMBL30164048 | 0.85 | LMNA (0.60) | GRM2DRD4DRD2DRD3KDM4E | |
| SCHEMBL31185228 | 0.84 | GRM2 (0.51) | GRM2DRD4DRD2DRD3KDM4E | |
| SCHEMBL24985354 | 0.84 | GRM2 (0.51) | GRM2DRD4DRD2DRD3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023006893-A1 | COMPOUNDS FOR THE TREATMENT OF PAIN, IN PARTICULAR NEUROPATHIC PAIN, AND/OR OTHER DISEASES OR DISORDERS THAT ARE ASSOCIATED WITH AT2R AND/OR AT2R MEDIATED SIGNALING | CONFO THERAPEUTICS N.V. (BE) | 2023-02-02 | — | — | WO | disclosed |