Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 6/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | RGS12 | O14924 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6267212 | 0.86 | CSNK1E (0.54) | AOC3LMNASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL19391254 | 0.84 | CSNK1E (0.57) | AOC3LMNASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10327288 | 0.84 | CSNK1E (0.57) | AOC3LMNASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL18759601 | 0.83 | LMNA (0.56) | AOC3LMNASLC6A2SLC6A4ADRA2C | |
| SCHEMBL18087746 | 0.82 | LMNA (0.60) | AOC3LMNASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6939841 | 0.82 | LMNA (0.60) | AOC3LMNASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL14402548 | 0.81 | AOC3 (0.50) | AOC3LMNAADRA2CKDM4EADRA2A | |
| SCHEMBL20738581 | 0.81 | AOC3 (0.50) | AOC3LMNAADRA2CKDM4EADRA2A | |
| SCHEMBL7531733 | 0.81 | AOC3 (0.59) | AOC3LMNASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL13849318 | 0.81 | AOC3 (0.50) | AOC3LMNAADRA2CKDM4EADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023014979-A9 | CONJUGATES COMPRISING COVALENT BINDERS FOR TARGETING INTRACELLULAR KRAS G12C PROTEINS | RAYZEBIO, INC. (US) | 2023-04-27 | — | — | WO | disclosed |
| WO-2023014979-A1 | CONJUGATES COMPRISING COVALENT BINDERS FOR TARGETING INTRACELLULAR KRAS G12C PROTEINS | RAYZEBIO, INC. (US) | 2023-02-09 | — | — | WO | disclosed |