SCHEMBL24991983

SCHEMBL24991983

CN(CCO)c1ccc(/C=C2\SC(=O)NC2=S)cc1

nearest known ligand 0.58

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 14/20 0.58
PNP P00491 1/20 0.58
PIM1 P11309 1/20 0.55
PIM2 Q9P1W9 1/20 0.55
HPGD P15428 3/20 0.54
MEN1 O00255 2/20 0.54
ALDH1A1 P00352 2/20 0.54
LMNA P02545 2/20 0.54
MAPT P10636 2/20 0.54
KMT2A Q03164 2/20 0.54
POLB P06746 1/20 0.54
MAPK1 P28482 1/20 0.54
RAB9A P51151 1/20 0.54
SMN1; SMN2 Q16637 1/20 0.54
CRHBP P24387 1/20 0.50
CRHR2 Q13324 1/20 0.50
RECQL P46063 1/20 0.50
PPARG P37231 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24992332 0.89 PIM1 (0.68) TDP1PIM1PIM2HPGDRAB9A
SCHEMBL24992356 0.85 CRHBP (0.71) PIM1PIM2MEN1KMT2APOLB
SCHEMBL24991897 0.83 TDP1 (0.50) TDP1PNPHPGDMEN1ALDH1A1
SCHEMBL8186777 0.82 PIM1 (0.74) TDP1PNPPIM1PIM2HPGD
SCHEMBL8186778 0.82 PIM1 (0.74) TDP1PNPPIM1PIM2HPGD
SCHEMBL24991910 0.79 TDP1 (0.50) TDP1PNPHPGDMEN1ALDH1A1
SCHEMBL16712246 0.76 MAPK1 (0.63) TDP1MEN1ALDH1A1LMNAMAPT
SCHEMBL24999933 0.76 PIM1 (0.51) TDP1PIM1PIM2HPGDRAB9A
SCHEMBL14860906 0.74 TDP1 (1.00) TDP1PNPHPGDMEN1ALDH1A1
SCHEMBL14860905 0.74 TDP1 (1.00) TDP1PNPHPGDMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023011657-A1 METHOD FOR DETECTING AND QUANTIFYING RNA 纳莹(上海)生物科技有限公司 2023-02-09 WO disclosed
WO-2023011658-A1 METHOD FOR DETECTING AND QUANTIFYING RNA 纳莹(上海)生物科技有限公司 2023-02-09 WO disclosed