Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 3/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MAP2K7 | O14733 | 2/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.35 |
| ▸ | BTK | Q06187 | 7/20 | 0.35 |
| ▸ | EGFR | P00533 | 4/20 | 0.35 |
| ▸ | CTSC | P53634 | 1/20 | 0.35 |
| ▸ | F13A1 | P00488 | 1/20 | 0.35 |
| ▸ | TGM2 | P21980 | 1/20 | 0.35 |
| ▸ | TGM1 | P22735 | 1/20 | 0.35 |
| ▸ | TGM3 | Q08188 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25589708 | 0.94 | ERBB2 (0.40) | MAP2K7ERBB2BTKEGFRCTSC | |
| SCHEMBL24992584 | 0.93 | FGFR1 (0.38) | FGFR4FGFR1FGFR2FGFR3CYP3A4 | |
| SCHEMBL25589193 | 0.93 | FGFR4 (0.39) | FGFR4FGFR1FGFR2FGFR3MAP2K7 | |
| SCHEMBL25589613 | 0.92 | FGFR1 (0.37) | FGFR4FGFR1FGFR2FGFR3CYP3A4 | |
| SCHEMBL25589195 | 0.92 | FGFR1 (0.41) | FGFR4FGFR1FGFR2FGFR3CYP3A4 | |
| SCHEMBL25589065 | 0.91 | ERBB2 (0.36) | FGFR4FGFR1FGFR2FGFR3MAP2K7 | |
| SCHEMBL25597424 | 0.91 | MAP2K7 (0.37) | FGFR4MAP2K7BTKEGFRCTSC | |
| SCHEMBL25589813 | 0.91 | MAP2K7 (0.37) | FGFR4FGFR1FGFR2FGFR3CYP3A4 | |
| SCHEMBL25597153 | 0.91 | FGFR4 (0.38) | FGFR4FGFR1FGFR2FGFR3CYP3A4 | |
| SCHEMBL25589069 | 0.91 | BTK (0.36) | FGFR4FGFR1MAP2K7ERBB2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023078413-A1 | FGFR2 INHIBITOR, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF | 微境生物医药科技(上海)有限公司 | 2023-05-11 | — | — | WO | disclosed |
| WO-2023011581-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATION THEREOF | 江苏恒瑞医药股份有限公司 | 2023-02-09 | — | — | WO | disclosed |