Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.73 |
| ▸ | BTK | Q06187 | 1/20 | 0.56 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.49 |
| ▸ | GSK3A | P49840 | 1/20 | 0.49 |
| ▸ | MAPK15 | Q8TD08 | 1/20 | 0.49 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.49 |
| ▸ | ULK1 | O75385 | 2/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.44 |
| ▸ | TTK | P33981 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25001489 | 0.93 | EGFR (0.84) | EGFRBTKLRRK2GSK3AMAPK15 | |
| SCHEMBL25001487 | 0.88 | EGFR (0.76) | EGFRBTKLRRK2GSK3AMAPK15 | |
| SCHEMBL27091391 | 0.88 | EGFR (0.75) | EGFRBTKLRRK2GSK3AMAPK15 | |
| SCHEMBL27091454 | 0.87 | EGFR (0.74) | EGFRBTKLRRK2GSK3AMAPK15 | |
| SCHEMBL23304015 | 0.85 | EGFR (1.00) | EGFRBTKLRRK2GSK3AMAPK15 | |
| SCHEMBL25001554 | 0.84 | EGFR (0.68) | EGFRBTKLRRK2ALK | |
| SCHEMBL30748473 | 0.83 | EGFR (0.68) | EGFRBTKULK1ALKTTK | |
| SCHEMBL25001760 | 0.83 | EGFR (0.68) | EGFRBTKULK1ALKTTK | |
| SCHEMBL12780221 | 0.83 | EGFR (0.71) | EGFRLRRK2GSK3AMAPK15CAMKK2 | |
| SCHEMBL30140980 | 0.82 | EGFR (0.66) | EGFRBTKLRRK2ULK1ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4129996-A1 | NOVEL AMINOPYRIMIDINE EGFR INHIBITOR | QILU PHARMACEUTICAL CO., LTD. (CN) | 2023-02-08 | — | — | EP | disclosed |