Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.33 |
| ▸ | ACE | P12821 | 1/20 | 0.33 |
| ▸ | CPA1 | P15085 | 1/20 | 0.33 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23489852 | 0.85 | ELANE (0.42) | ELANEALDH1A1ESR1KCNH2L3MBTL1 | |
| SCHEMBL8354598 | 0.78 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1CTSSCTSKSMN1; SMN2 | |
| SCHEMBL18771241 | 0.78 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1CTSSCTSKSMN1; SMN2 | |
| SCHEMBL12537194 | 0.78 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1CTSSCTSKSMN1; SMN2 | |
| SCHEMBL9344459 | 0.75 | SMN1; SMN2 (0.47) | ALDH1A1ESR1KCNH2EPHX1POLB | |
| SCHEMBL12018403 | 0.74 | ALDH1A1 (0.43) | ALDH1A1L3MBTL1NOS3NOS1NOS2 | |
| SCHEMBL23084126 | 0.74 | ALDH1A1 (0.47) | ALDH1A1L3MBTL1CTSSCTSKSMN1; SMN2 | |
| SCHEMBL3265293 | 0.74 | ALDH1A1 (0.43) | ALDH1A1L3MBTL1NOS3NOS1NOS2 | |
| SCHEMBL5988691 | 0.74 | ALDH1A1 (0.43) | ALDH1A1L3MBTL1NOS3NOS1NOS2 | |
| SCHEMBL20793416 | 0.73 | ALDH1A1 (0.44) | ALDH1A1L3MBTL1CTSSCTSKSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230045142-A1 | SMALL MOLECULE RPN13 INHIBITORS WITH ANTITUMOR PROPERTIES | THE JOHNS HOPKINS UNIVERSITY (US) | 2023-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230045142-A1 | SMALL MOLECULE RPN13 INHIBITORS WITH ANTITUMOR PROPERTIES | MRPS23, RPP30, RPS19 | ELANE 3318/4885ALDH1A1 3385/4885ESR1 2627/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.