SCHEMBL2500453

SCHEMBL2500453

COc1cc(C)c(OC)c(C)c1OC

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 1/20 0.54
CYP3A4 P08684 1/20 0.46
MAPT P10636 1/20 0.46
CA9 Q16790 1/20 0.46
PTGS2 P35354 1/20 0.43
TUBB1 Q9H4B7 3/20 0.41
CYP19A1 P11511 4/20 0.40
NQO2 P16083 4/20 0.40
TUBB4A P04350 2/20 0.39
TUBB P07437 2/20 0.39
TUBA3C P0DPH7 2/20 0.39
TUBA1B P68363 2/20 0.39
TUBA4A P68366 2/20 0.39
TUBB4B P68371 2/20 0.39
TUBB3 Q13509 2/20 0.39
TUBB2A Q13885 2/20 0.39
TUBB8 Q3ZCM7 2/20 0.39
TUBA3E Q6PEY2 2/20 0.39
TUBA1A Q71U36 2/20 0.39
TUBA1C Q9BQE3 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29793476 0.87 ACHE (0.50) ACHECYP3A4MAPTCA9PTGS2
SCHEMBL1635426 0.87 ACHE (0.50) ACHECYP3A4MAPTCA9PTGS2
SCHEMBL3356035 0.87 ACHE (0.62) ACHECYP3A4MAPTCA9PTGS2
Iodide SCHEMBL8935417 0.85 ACHE (0.48) ACHECYP3A4MAPTCA9PTGS2
SCHEMBL14458264 0.85 ACHE (0.54) ACHECYP3A4MAPTCA9PTGS2
Iodobenzene SCHEMBL28037168 0.83 TUBB1 (0.42) ACHEMAPTCA9TUBB1TUBB4A
Bromide SCHEMBL8935516 0.83 ACHE (0.46) ACHECYP3A4MAPTCA9PTGS2
Bromide SCHEMBL8935512 0.83 ACHE (0.46) ACHECYP3A4MAPTCA9PTGS2
SCHEMBL1243920 0.82 ACHE (0.56) ACHECYP3A4MAPTCA9PTGS2
SCHEMBL30835564 0.82 ACHE (0.56) ACHECYP3A4MAPTCA9PTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 92 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4011921-B1 RUBBER WITH BACKBONE AND END-GROUP FUNCTIONALIZATION AND ITS METHOD OF MANUFACTURING AND USE IN A TIRE G 3 CHICKADEE PURCHASER LLC 1485 E ARCHWOOD AVENUE (US) 2026-02-04 EP disclosed
CN-114621375-B Rubber with backbone and end-group functionalization 固特异轮胎和橡胶公司 2024-06-18 CN disclosed
US-11912798-B2 Rubber with backbone and end-group functionalization THE GOODYEAR TIRE & RUBBER COMPANY (US) 2024-02-27 US disclosed
US-20230312798-A1 FUNCTIONALIZED HYDROGENATED POLYMERS MIZUHO BANK, LTD., AS ADMINISTRATIVE AGENT 2023-10-05 US disclosed
EP-4011921-A1 RUBBER WITH BACKBONE AND END-GROUP FUNCTIONALIZATION AND ITS METHOD OF MANUFACTURING AND USE IN A TIRE The Goodyear Tire & Rubber Company (US) 2022-06-15 EP disclosed
CN-114621375-A Rubber with main chain and end group functionalization 固特异轮胎和橡胶公司 2022-06-14 CN disclosed
US-20220177610-A1 RUBBER WITH BACKBONE AND END-GROUP FUNCTIONALIZATION MIZUHO BANK, LTD., AS ADMINISTRATIVE AGENT 2022-06-09 US disclosed
EP-3313927-B1 DILITHIUM INITIATORS FINA TECHNOLOGY (US) 2021-12-15 EP disclosed
EP-2911656-B1 QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS FOR OPHTHALMIC USE NICOX SA (FR) 2020-12-02 EP disclosed
CN-107922678-B Dilithium initiators 飞纳技术有限公司 2020-04-07 CN disclosed
EP-0761703-A1 Isoprene-butadiene diblock rubber THE GOODYEAR TIRE & RUBBER COMPANY (US) 1997-03-12 EP disclosed
US-5534592-A POLYBUTADIENE RUBBER BLEND THE GOODYEAR TIRE & RUBBER COMPANY (US) 1996-07-09 US disclosed
EP-0438967-B1 Segmented elastomer GOODYEAR TIRE & RUBBER (US) 1996-05-01 EP disclosed
US-5239009-A Butadiene, isoprene, styrene random polymer, wear resistance, good traction tire treads THE GOODYEAR TIRE & RUBBER COMPANY (US) 1993-08-24 US disclosed
US-5202387-A Modified styrene-butadiene copolymer; catalytic polymerization using living-catalyst THE GOODYEAR TIRE & RUBBER COMPANY (US) 1993-04-13 US disclosed
US-5100965-A Process for synthesizing high trans polymers THE GOODYEAR TIRE & RUBBER COMPANY (US) 1992-03-31 US disclosed
US-5070148-A SEGMENTED ELASTOMER THE GOODYEAR TIRE & RUBBER COMPANY (US) 1991-12-03 US disclosed
EP-0438967-A1 Segmented elastomer THE GOODYEAR TIRE & RUBBER COMPANY (US) 1991-07-31 EP disclosed
EP-0258167-A2 Modifier for lithium catalysts THE GOODYEAR TIRE & RUBBER COMPANY (US) 1988-03-02 EP disclosed
US-4696986-A 1,2,3- OR 1,2,4-TRIALKOXYBENZENE MODIFIERS THE GOODYEAR TIRE & RUBBER COMPANY (US) 1987-09-29 US disclosed