Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1C | Q14123 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.36 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.36 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.35 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23994880 | 0.80 | HTR2A (0.45) | SLC6A4HTR2CHTR2BHTR2A | |
| SCHEMBL23995200 | 0.80 | HTR2C (0.34) | SLC6A4SLC6A2SLC6A3HTR2CHTR2B | |
| SCHEMBL23994874 | 0.79 | SLC6A4 (0.36) | PDE1CSLC6A4SLC6A2SLC6A3HTR2C | |
| SCHEMBL23994574 | 0.79 | SLC6A4 (0.36) | SLC6A4SLC6A2SLC6A3HTR2CHTR2B | |
| SCHEMBL23995267 | 0.78 | PDE1C (0.43) | PDE1CNOTUMHTR2CHTR2BHDAC4 | |
| SCHEMBL29855932 | 0.76 | HDAC4 (0.49) | PDE1CSLC6A4NOTUMHDAC4ERCC1 | |
| SCHEMBL10288759 | 0.76 | PDE1C (0.49) | PDE1CNOTUMHDAC4ERCC1ERCC4 | |
| SCHEMBL10289076 | 0.76 | PDE1C (0.49) | PDE1CNOTUMHDAC4ERCC1ERCC4 | |
| SCHEMBL2137211 | 0.76 | PDE1C (0.49) | PDE1CNOTUMHDAC4ERCC1ERCC4 | |
| SCHEMBL2134501 | 0.74 | PDE1C (0.50) | PDE1CSLC6A4SLC6A3HDAC4CDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230039553-A1 | CD73 COMPOUNDS | GILEAD SCIENCES, INC. | 2023-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230039553-A1 | CD73 COMPOUNDS | ENTPD5, ENTPD1, NT5E | PDE1C 2728/4885SLC6A4 1120/4885NOTUM 3908/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.