Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | IDO1 | P14902 | 1/20 | 0.52 |
| ▸ | TDO2 | P48775 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.47 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10369216 | 0.95 | GAA (0.55) | GAAIDO1TDO2ATMSMN1; SMN2 | |
| SCHEMBL11883145 | 0.83 | GAA (0.39) | GAAIDO1TDO2ATMSMN1; SMN2 | |
| SCHEMBL5486391 | 0.82 | MMP2 (0.55) | PDK2PDK4MMP2MMP9 | |
| SCHEMBL8056975 | 0.81 | GAA (0.61) | GAAIDO1TDO2ATMSMN1; SMN2 | |
| SCHEMBL25927823 | 0.81 | MMP2 (0.54) | PDK2PDK4MMP2MMP9 | |
| SCHEMBL28140642 | 0.80 | MMP2 (0.50) | PDK2PDK4PKMMMP2MMP9 | |
| SCHEMBL31678591 | 0.80 | MMP2 (0.44) | GAAIDO1TDO2ALDH1A1MAPT | |
| SCHEMBL17866770 | 0.80 | MMP2 (0.44) | GAAIDO1TDO2ALDH1A1MAPT | |
| SCHEMBL17867359 | 0.80 | MMP2 (0.44) | GAAIDO1TDO2ALDH1A1MAPT | |
| SCHEMBL8091150 | 0.79 | PDK2 (0.46) | GAAALDH1A1LMNAPDK2PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160106711-A1 | 3-3-Di-Substituted-Oxindoles as Inhibitors of Translation Initiation | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-04-21 | — | — | US | disclosed |
| WO-2014047437-A1 | 3-3-DI-SUBSTITUTED-OXINDOLES AS INHIBITORS OF TRANSLATION INITIATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-03-27 | — | — | WO | disclosed |
| US-8354440-B2 | 3-3-di-substituted-oxindoles as inhibitors of translation initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-01-15 | — | — | US | disclosed |
| US-8268879-B2 | 3-3-di-substituted-oxindoles as inhibitors of translation initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-09-18 | — | — | US | disclosed |
| US-20120077759-A1 | 3-3-Di-Substituted-Oxindoles as Inhibitors of Translation Initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-03-29 | — | — | US | disclosed |
| US-8088816-B2 | 3-3-di-substituted-oxindoles as inhibitors of translation initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-01-03 | — | — | US | disclosed |
| US-8044089-B2 | 3-3-di-substituted-oxindoles as inhibitors of translation initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-10-25 | — | — | US | disclosed |
| US-20110046367-A1 | 3-3-DI-SUBSTITUTED-OXINDOLES AS INHIBITORS OF TRANSLATION INITIATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-02-24 | — | — | US | disclosed |
| US-7846962-B2 | 3-3-di-substituted-oxindoles as inhibitors of translation initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-12-07 | — | — | US | disclosed |
| US-20100256388-A1 | 3-3-Di-Substituted-Oxindoles As Inhibitors of Translation Initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-10-07 | — | — | US | disclosed |
| US-20100249201-A1 | 3-3-Di-Substituted-Oxindoles As Inhibitors of Translation Initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-09-30 | — | — | US | disclosed |
| US-7737172-B2 | 3-3-di-substituted-oxindoles as inhibitors of translation initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-06-15 | — | — | US | disclosed |
| US-20090299058-A1 | 3-3-DI-SUBSTITUTED-OXINDOLES AS INHIBITORS OF TRANSLATION INITIATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2009-12-03 | — | — | US | disclosed |
| US-20070099976-A1 | 3-3-DI-SUBSTITUTED-OXINDOLES AS INHIBITORS OF TRANSLATION INITIATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2007-05-03 | — | — | US | disclosed |
| EP-1718611-A1 | 3-3-DI-SUBSTITUTED-OXINDOLES AS INHIBITORS OF TRANSLATION INITIATION | The President and Fellows of Harvard College (US) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005080335-A1 | 3-3-DI-SUBSTITUTED-OXINDOLES AS INHIBITORS OF TRANSLATION INITIATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2005-09-01 | — | — | WO | disclosed |
| EP-0747354-B1 | 3-Substituted oxindole derivatives as potassium channel modulators | BRISTOL MYERS SQUIBB CO (US) | 2000-08-16 | — | — | EP | disclosed |
| US-5602169-A | USEFUL IN REDUCING NEURONAL DAMAGE DURING ISCHEMIC STROKE | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-02-11 | — | — | US | disclosed |
| EP-0747354-A1 | 3-Substituted oxindole derivatives as potassium channel modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |
| US-5565483-A | ADMINISTERING AS THERAPY FOR ISCHEMIA, CONVULSIONS OR ASTHMA | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256388-A1 | 3-3-Di-Substituted-Oxindoles As Inhibitors of Translation Initiation | EIF2AK2, EIF5B, EIF4EBP1 | GAA 3345/4885IDO1 501/4885TDO2 1021/4885 |
| US-20090299058-A1 | 3-3-DI-SUBSTITUTED-OXINDOLES AS INHIBITORS OF TRANSLATION INITIATION | EIF2AK2, EIF5B, EIF4EBP1 | GAA 3345/4885IDO1 501/4885TDO2 1021/4885 |
| US-20070099976-A1 | 3-3-DI-SUBSTITUTED-OXINDOLES AS INHIBITORS OF TRANSLATION INITIATION | EIF2AK2, EIF5B, EIF4EBP1 | GAA 3345/4885IDO1 501/4885TDO2 1021/4885 |
| US-20120077759-A1 | 3-3-Di-Substituted-Oxindoles as Inhibitors of Translation Initiation | EIF2AK2, EIF5B, EIF4EBP1 | GAA 3345/4885IDO1 501/4885TDO2 1021/4885 |
| US-20160106711-A1 | 3-3-Di-Substituted-Oxindoles as Inhibitors of Translation Initiation | RIOX2, EIF4A3, RPL35 | GAA 3729/4885IDO1 2172/4885TDO2 1181/4885 |
| US-20110046367-A1 | 3-3-DI-SUBSTITUTED-OXINDOLES AS INHIBITORS OF TRANSLATION INITIATION | EIF2AK2, EIF5B, EIF4EBP1 | GAA 3345/4885IDO1 501/4885TDO2 1021/4885 |
| US-20100249201-A1 | 3-3-Di-Substituted-Oxindoles As Inhibitors of Translation Initiation | EIF2AK2, EIF5B, EIF4EBP1 | GAA 3345/4885IDO1 501/4885TDO2 1021/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.