Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.66 |
| ▸ | GAA | P10253 | 5/20 | 0.66 |
| ▸ | HPGD | P15428 | 7/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25010542 | 0.87 | POLB (0.60) | POLBALDH1A1KDM4EGAAHPGD | |
| SCHEMBL25009690 | 0.86 | MAPT (0.60) | POLBMAPTNAMPT | |
| SCHEMBL19001281 | 0.84 | ALDH1A1 (0.69) | POLBALDH1A1KDM4EGAAHPGD | |
| SCHEMBL19001178 | 0.82 | POLB (0.60) | POLBALDH1A1KDM4EGAAHPGD | |
| SCHEMBL12578243 | 0.81 | ALDH1A1 (0.69) | POLBALDH1A1KDM4EGAAHPGD | |
| SCHEMBL25009417 | 0.81 | ALDH1A1 (0.76) | POLBALDH1A1KDM4EGAAHPGD | |
| SCHEMBL20467410 | 0.81 | ALDH1A1 (0.81) | POLBALDH1A1KDM4EGAAHPGD | |
| SCHEMBL20467545 | 0.80 | ALDH1A1 (0.79) | POLBALDH1A1KDM4EGAAHPGD | |
| SCHEMBL9823141 | 0.79 | ALDH1A1 (0.76) | POLBALDH1A1KDM4EGAAHPGD | |
| SCHEMBL21843716 | 0.79 | ALDH1A1 (0.71) | POLBALDH1A1KDM4EGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230041576-A1 | METHODS AND MATERIALS FOR INHIBITING NF-kB ACTIVITY | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2023-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230041576-A1 | METHODS AND MATERIALS FOR INHIBITING NF-kB ACTIVITY | NFKBIA, IKBKB, NFKB2 | POLB 47/4885ALDH1A1 4286/4885KDM4E 2556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.