Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.90 |
| ▸ | MAPT | P10636 | 8/20 | 0.80 |
| ▸ | TP53 | P04637 | 6/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.80 |
| ▸ | TSHR | P16473 | 3/20 | 0.80 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.80 |
| ▸ | HPGD | P15428 | 3/20 | 0.80 |
| ▸ | HTT | P42858 | 2/20 | 0.80 |
| ▸ | LMNA | P02545 | 1/20 | 0.80 |
| ▸ | MEN1 | O00255 | 3/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.77 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.77 |
| ▸ | POLB | P06746 | 4/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25010436 | 1.00 | KDM4E (0.90) | KDM4EMAPTTP53ALDH1A1TSHR | |
| SCHEMBL25010433 | 0.95 | KDM4E (1.00) | KDM4EMAPTTP53ALDH1A1TSHR | |
| SCHEMBL25011046 | 0.89 | KDM4E (0.88) | KDM4EMAPTTP53ALDH1A1TSHR | |
| SCHEMBL25010067 | 0.89 | TP53 (1.00) | KDM4EMAPTTP53ALDH1A1TSHR | |
| SCHEMBL22857115 | 0.89 | HSD17B10 (1.00) | KDM4EMAPTTP53ALDH1A1TSHR | |
| SCHEMBL25010121 | 0.89 | ALDH1A1 (1.00) | KDM4EMAPTTP53ALDH1A1TSHR | |
| SCHEMBL25010448 | 0.88 | ALDH1A1 (0.77) | KDM4EMAPTTP53ALDH1A1TSHR | |
| SCHEMBL25009620 | 0.87 | TSHR (0.75) | KDM4EMAPTTP53ALDH1A1TSHR | |
| SCHEMBL25009333 | 0.87 | TSHR (0.75) | KDM4EMAPTTP53ALDH1A1TSHR | |
| SCHEMBL25009183 | 0.87 | KDM4E (0.68) | KDM4EMAPTTP53ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230041576-A1 | METHODS AND MATERIALS FOR INHIBITING NF-kB ACTIVITY | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2023-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230041576-A1 | METHODS AND MATERIALS FOR INHIBITING NF-kB ACTIVITY | NFKBIA, IKBKB, NFKB2 | KDM4E 2556/4885MAPT 2111/4885TP53 376/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.