Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.77 |
| ▸ | GAA | P10253 | 4/20 | 0.77 |
| ▸ | HPGD | P15428 | 4/20 | 0.77 |
| ▸ | POLB | P06746 | 1/20 | 0.73 |
| ▸ | TP53 | P04637 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | NAMPT | P43490 | 8/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13410503 | 0.88 | HPGD (0.59) | ALDH1A1KDM4EGAAHPGDPOLB | |
| SCHEMBL25009235 | 0.88 | MAPT (0.68) | NAMPT | |
| SCHEMBL20467544 | 0.87 | ALDH1A1 (1.00) | ALDH1A1KDM4EGAAHPGDPOLB | |
| SCHEMBL20467510 | 0.86 | ALDH1A1 (0.79) | ALDH1A1KDM4EGAAHPGDPOLB | |
| SCHEMBL21843716 | 0.85 | ALDH1A1 (0.71) | ALDH1A1KDM4EGAAHPGDPOLB | |
| SCHEMBL20467453 | 0.85 | ALDH1A1 (0.86) | ALDH1A1KDM4EGAAHPGDPOLB | |
| SCHEMBL20467410 | 0.84 | ALDH1A1 (0.81) | ALDH1A1KDM4EGAAHPGDPOLB | |
| SCHEMBL25009417 | 0.84 | ALDH1A1 (0.76) | ALDH1A1KDM4EGAAHPGDPOLB | |
| SCHEMBL20467509 | 0.84 | ALDH1A1 (0.84) | ALDH1A1KDM4EGAAHPGDPOLB | |
| SCHEMBL25009174 | 0.82 | ALDH1A1 (0.76) | ALDH1A1KDM4EGAAHPGDTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230041576-A1 | METHODS AND MATERIALS FOR INHIBITING NF-kB ACTIVITY | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2023-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230041576-A1 | METHODS AND MATERIALS FOR INHIBITING NF-kB ACTIVITY | NFKBIA, IKBKB, NFKB2 | ALDH1A1 4286/4885KDM4E 2556/4885GAA 403/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.