Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | GAA | P10253 | 3/20 | 0.65 |
| ▸ | HPGD | P15428 | 3/20 | 0.65 |
| ▸ | RAD52 | P43351 | 2/20 | 0.65 |
| ▸ | GALK1 | P51570 | 1/20 | 0.65 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | NAMPT | P43490 | 8/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | AKT1 | P31749 | 1/20 | 0.51 |
| ▸ | AKT2 | P31751 | 1/20 | 0.51 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25009208 | 0.86 | MEN1 (0.98) | MEN1KMT2AKDM4EALDH1A1GAA | |
| SCHEMBL25009221 | 0.84 | MEN1 (0.82) | MEN1KMT2AKDM4EALDH1A1GAA | |
| SCHEMBL25009697 | 0.82 | MEN1 (0.72) | MEN1KMT2AKDM4EALDH1A1GAA | |
| SCHEMBL25009226 | 0.82 | RAD52 (0.72) | MEN1KMT2AKDM4EALDH1A1GAA | |
| SCHEMBL25010296 | 0.80 | KMT2A (0.71) | MEN1KMT2AKDM4EALDH1A1GAA | |
| SCHEMBL20467544 | 0.80 | ALDH1A1 (1.00) | MEN1KMT2AKDM4EALDH1A1GAA | |
| SCHEMBL16495798 | 0.79 | SLC6A2 (0.58) | HPGDSLC6A2SLC6A4 | |
| SCHEMBL25011159 | 0.78 | RAD52 (1.00) | MEN1KMT2AKDM4EALDH1A1GAA | |
| SCHEMBL25011151 | 0.78 | RAD52 (0.87) | MEN1KMT2AKDM4EALDH1A1GAA | |
| SCHEMBL20467453 | 0.78 | ALDH1A1 (0.86) | MEN1KMT2AKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230041576-A1 | METHODS AND MATERIALS FOR INHIBITING NF-kB ACTIVITY | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2023-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230041576-A1 | METHODS AND MATERIALS FOR INHIBITING NF-kB ACTIVITY | NFKBIA, IKBKB, NFKB2 | MEN1 2504/4885KMT2A 2885/4885KDM4E 2556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.