Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 8/20 | 0.80 |
| ▸ | TP53 | P04637 | 4/20 | 0.73 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25009089 | 0.89 | MAPT (0.69) | PKMTP53POLBMAPTLMNA | |
| SCHEMBL25009095 | 0.86 | PKM (0.80) | PKMTP53POLBLMNA | |
| SCHEMBL25010369 | 0.83 | PKM (0.82) | PKMTP53POLBMAPTLMNA | |
| SCHEMBL25009493 | 0.83 | PKM (0.82) | PKMTP53POLBMAPTLMNA | |
| SCHEMBL25010014 | 0.81 | PKM (1.00) | PKMTP53POLBLMNA | |
| SCHEMBL25009227 | 0.80 | PKM (0.83) | PKMTP53POLBLMNA | |
| SCHEMBL25009096 | 0.79 | PKM (0.70) | PKMTP53POLBMAPTLMNA | |
| SCHEMBL25010896 | 0.79 | PKM (0.79) | PKMTP53POLBLMNA | |
| SCHEMBL25010387 | 0.78 | TP53 (0.82) | PKMTP53POLBMAPTLMNA | |
| SCHEMBL25010007 | 0.78 | PKM (0.78) | PKMTP53POLBMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230041576-A1 | METHODS AND MATERIALS FOR INHIBITING NF-kB ACTIVITY | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2023-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230041576-A1 | METHODS AND MATERIALS FOR INHIBITING NF-kB ACTIVITY | NFKBIA, IKBKB, NFKB2 | PKM 2499/4885TP53 376/4885POLB 47/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.