Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.30 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4345504 | 0.90 | HRH4 (0.42) | HRH4PTPN1HRH3SSTR2SSTR4 | |
| Trifluoroacetic Acid SCHEMBL2501172 | 0.87 | HRH4 (0.35) | HRH4ADORA2AADORA1SSTR2SSTR4 | |
| SCHEMBL603126 | 0.75 | HRH4 (0.41) | HRH4HRH3SSTR2SSTR4 | |
| Trifluoroacetic Acid SCHEMBL2493686 | 0.71 | HRH4 (0.38) | HRH4ADORA2AADORA1 | |
| Trifluoroacetic Acid SCHEMBL2498377 | 0.67 | HRH4 (0.83) | HRH4HRH3 | |
| Trifluoroacetic Acid SCHEMBL2493826 | 0.65 | HRH4 (0.39) | HRH4 | |
| Trifluoroacetic Acid SCHEMBL4528055 | 0.64 | MAP4K4 (0.43) | PTPN1 | |
| Trifluoroacetic Acid SCHEMBL2499846 | 0.64 | HRH4 (0.81) | HRH4 | |
| Trifluoroacetic Acid SCHEMBL3739182 | 0.61 | PTPN1 (0.80) | PTPN1 | |
| Trifluoroacetic Acid SCHEMBL4533732 | 0.61 | PTPN1 (0.52) | HRH4PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8030321-B2 | Benzofuro- and benzothienopyrimidine modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA, NV (BE) | 2011-10-04 | — | — | US | disclosed |
| US-20090325927-A1 | Benzofuro- and benzothienopyrimidine modulators of the histamine H4 receptor | CHAVEZ FRANK | 2009-12-31 | — | — | US | disclosed |
| US-7576092-B2 | Benzofuro- and benzothienopyrimidine modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-08-18 | — | — | US | disclosed |
| US-20080015200-A1 | Benzofuro- and benzothienopyrimidine modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080015200-A1 | Benzofuro- and benzothienopyrimidine modulators of the histamine H4 receptor | HRH4, HRH1, HRH2 | HRH4 1/4885ADORA2A 643/4885ADORA1 356/4885 |
| US-20090325927-A1 | Benzofuro- and benzothienopyrimidine modulators of the histamine H4 receptor | HRH4, HRH1, HRH2 | HRH4 1/4885ADORA2A 643/4885ADORA1 356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.