Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 4/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 9/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | TRIM58 | Q8NG06 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4524783 | 0.88 | MAP4K4 (0.52) | MAP4K4DHFRPTPN1NLRP3TRIM58 | |
| Trifluoroacetic Acid SCHEMBL4525618 | 0.87 | DHFR (0.52) | MAP4K4DHFRPTPN1NLRP3TRIM58 | |
| Trifluoroacetic Acid SCHEMBL4521116 | 0.87 | PTPN1 (0.48) | MAP4K4DHFRPTPN1 | |
| Trifluoroacetic Acid SCHEMBL4528549 | 0.85 | DHFR (0.50) | MAP4K4DHFRPTPN1TRIM58 | |
| Trifluoroacetic Acid SCHEMBL4533732 | 0.85 | PTPN1 (0.52) | MAP4K4PTPN1KMT2AHSP90AB1 | |
| Trifluoroacetic Acid SCHEMBL4533714 | 0.84 | PTPN1 (0.49) | DHFRPTPN1GSK3B | |
| Trifluoroacetic Acid SCHEMBL5499368 | 0.83 | PTPN1 (0.39) | DHFRPTPN1NLRP3 | |
| Trifluoroacetic Acid SCHEMBL4529413 | 0.83 | DHFR (0.40) | DHFRPTPN1NLRP3GSK3BTRIM58 | |
| Trifluoroacetic Acid SCHEMBL4524510 | 0.83 | PTPN1 (0.50) | DHFRPTPN1 | |
| Trifluoroacetic Acid SCHEMBL4526540 | 0.82 | PTPN1 (0.48) | DHFRPTPN1TRIM58 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812409-A1 | AMINOQUINAZOLINES COMPOUNDS | F. Hoffmann-Roche AG (CH) | 2007-08-01 | — | — | EP | claimed |
| WO-2006050843-A1 | AMINOQUINAZOLINES COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-05-18 | — | — | WO | claimed |
| US-20090105477-A1 | Quinazoline Protein Tyrosine Phosphatase Inhibitors | BERTHEL STEVEN JOSEPH | 2009-04-23 | — | — | US | disclosed |
| EP-1812409-A1 | AMINOQUINAZOLINES COMPOUNDS | F. Hoffmann-Roche AG (CH) | 2007-08-01 | — | — | EP | disclosed |
| US-20060211715-A1 | Quinazoline protein tyrosine phosphatase inhibitors | BERTHEL STEVEN J | 2006-09-21 | — | — | US | disclosed |
| WO-2006050843-A1 | AMINOQUINAZOLINES COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105477-A1 | Quinazoline Protein Tyrosine Phosphatase Inhibitors | PTPN5, PTPN1, PTPN7 | MAP4K4 639/4885DHFR 2071/4885PTPN1 2/4885 |
| US-20060211715-A1 | Quinazoline protein tyrosine phosphatase inhibitors | PTPN5, PTPN1, PTPN7 | MAP4K4 639/4885DHFR 2071/4885PTPN1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.