Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 4/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.36 |
| ▸ | PLG | P00747 | 2/20 | 0.35 |
| ▸ | F10 | P00742 | 8/20 | 0.35 |
| ▸ | F2 | P00734 | 4/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA7 | P43166 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.34 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.34 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.34 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25016298 | 0.95 | NAMPT (0.35) | ITGB3ITGA2BPLGF10F2 | |
| SCHEMBL25016289 | 0.89 | F10 (0.39) | PLGF10F2PRSS1CA12 | |
| SCHEMBL25016269 | 0.86 | NPC1 (0.43) | F10F2PRSS1CA12CA1 | |
| SCHEMBL25015870 | 0.84 | ST14 (0.48) | PLGF10F2PRSS1 | |
| SCHEMBL25016132 | 0.83 | CNR2 (0.40) | ITGB3ITGA2BF10F2TPSAB1 | |
| SCHEMBL25015831 | 0.82 | F10 (0.40) | ITGB3ITGA2BF10F2PRSS1 | |
| SCHEMBL25017361 | 0.82 | HRH3 (0.40) | ITGB3ITGA2BF10F2PRSS1 | |
| SCHEMBL25015749 | 0.81 | F2 (0.45) | PLGF10F2PRSS1 | |
| SCHEMBL25017863 | 0.80 | F10 (0.45) | ITGB3ITGA2BF10F2PRSS1 | |
| SCHEMBL25017891 | 0.78 | F10 (0.44) | PLGF10F2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230043159-A1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | DISC MEDICINE, INC. | 2023-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230043159-A1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | MMP7, MATR3, SPINT2 | ITGB3 2374/4885ITGA2B 2429/4885PLG 225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.