Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 12/20 | 0.43 |
| ▸ | F2 | P00734 | 4/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.41 |
| ▸ | ST14 | Q9Y5Y6 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25017906 | 0.90 | F10 (0.44) | TLR9TLR7MCHR1F10F2 | |
| SCHEMBL25017196 | 0.86 | F10 (0.47) | TLR9TLR7MCHR1F10F2 | |
| SCHEMBL25016024 | 0.86 | ST14 (0.43) | MCHR1F10F2PRSS1PRSS2 | |
| SCHEMBL25017106 | 0.85 | F10 (0.49) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL25017123 | 0.85 | F10 (0.49) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL25016829 | 0.83 | F10 (0.41) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL25016220 | 0.82 | F10 (0.43) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL25015926 | 0.82 | ST14 (0.45) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL25016558 | 0.82 | F10 (0.43) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL25016348 | 0.82 | F10 (0.46) | F10F2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230043159-A1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | DISC MEDICINE, INC. | 2023-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230043159-A1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | MMP7, MATR3, SPINT2 | TLR9 3554/4885TLR7 4153/4885MCHR1 3680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.