⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL838325 | 0.86 | EPHX2 (0.33) | — | |
| SCHEMBL20283648 | 0.74 | — | — | |
| SCHEMBL18552722 | 0.74 | — | — | |
| SCHEMBL18639307 | 0.74 | HDAC6 (0.36) | — | |
| SCHEMBL19102108 | 0.74 | — | — | |
| SCHEMBL17775925 | 0.74 | — | — | |
| SCHEMBL4115893 | 0.72 | CTSK (0.30) | — | |
| SCHEMBL17635541 | 0.70 | — | — | |
| SCHEMBL14085830 | 0.70 | KDM4E (0.37) | — | |
| SCHEMBL25017779 | 0.70 | GRIN1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230381148-A1 | HDAC6 INHIBITORS FOR TREATMENT OF METABOLIC DISEASE AND HFPEF | TENAYA THERAPEUTICS, INC. | 2023-11-30 | — | — | US | disclosed |
| US-20230143804-A1 | FLUOROALKYL-OXADIAZOLES AND USES THEREOF | TENAYA THERAPEUTICS, INC. | 2023-05-11 | — | — | US | disclosed |
| US-11578066-B1 | Fluoroalkyl-oxadiazoles and uses thereof | TENAYA THERAPEUTICS, INC. (US) | 2023-02-14 | — | — | US | disclosed |