Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT6 | P42226 | 8/20 | 0.51 |
| ▸ | JAK3 | P52333 | 6/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.46 |
| ▸ | JAK1 | P23458 | 3/20 | 0.46 |
| ▸ | TYK2 | P29597 | 3/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | SYK | P43405 | 5/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.42 |
| ▸ | CYP21A2 | P08686 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.41 |
| ▸ | STK4 | Q13043 | 2/20 | 0.41 |
| ▸ | STK3 | Q13188 | 2/20 | 0.41 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.41 |
| ▸ | RPS6KA6 | Q9UK32 | 2/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2508033 | 0.97 | STAT6 (0.53) | STAT6JAK3IRAK4JAK1TYK2 | |
| SCHEMBL2483459 | 0.90 | STAT6 (0.47) | STAT6JAK3IRAK4JAK1TYK2 | |
| SCHEMBL2485587 | 0.89 | JAK3 (0.49) | STAT6JAK3IRAK4JAK1TYK2 | |
| SCHEMBL2485542 | 0.88 | STAT6 (0.55) | STAT6JAK3IRAK4JAK1TYK2 | |
| SCHEMBL2477813 | 0.88 | STAT6 (0.53) | STAT6JAK3IRAK4JAK1TYK2 | |
| SCHEMBL12301690 | 0.86 | STAT6 (0.60) | STAT6JAK3IRAK4JAK1TYK2 | |
| SCHEMBL12301702 | 0.86 | STAT6 (0.52) | STAT6JAK3IRAK4JAK1TYK2 | |
| SCHEMBL2476949 | 0.86 | STAT6 (0.56) | STAT6JAK3IRAK4JAK1TYK2 | |
| SCHEMBL2504310 | 0.85 | JAK3 (0.55) | STAT6JAK3IRAK4JAK1TYK2 | |
| SCHEMBL2507016 | 0.85 | STAT6 (0.53) | STAT6JAK3IRAK4JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8575153-B2 | Pyridine-3-carboxyamide derivative | KOWA COMPANY, LTD. (JP) | 2013-11-05 | — | — | US | disclosed |
| EP-2380877-A1 | PYRIDINE-3-CARBOXYAMIDE DERIVATIVE | Kowa Company, Ltd. (JP) | 2011-10-26 | — | — | EP | disclosed |
| US-20110237590-A1 | PYRIDINE-3-CARBOXYAMIDE DERIVATIVE | KOWA COMPANY, LTD. (JP) | 2011-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110237590-A1 | PYRIDINE-3-CARBOXYAMIDE DERIVATIVE | JAK3, JAK1, UACA | STAT6 8/4885JAK3 1/4885IRAK4 128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.