Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.64 |
| ▸ | CCR2 | P41597 | 4/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.35 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ACLY | P53396 | 1/20 | 0.32 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1762385 | 0.89 | CYP3A4 (0.79) | CYP3A4CCR2CYP2C9JAK1TSHR | |
| SCHEMBL22461745 | 0.89 | CYP3A4 (0.67) | CYP3A4CCR2CYP2C9NUDT1JAK1 | |
| SCHEMBL306072 | 0.86 | CYP2C9 (0.65) | CYP3A4CCR2CYP2C9CYP2C19 | |
| SCHEMBL26066327 | 0.84 | CYP3A4 (0.56) | CYP3A4CCR2CYP2C9NUDT1CYP2C19 | |
| SCHEMBL306637 | 0.83 | CYP2C9 (0.77) | CYP3A4CCR2CYP2C9TSHR | |
| SCHEMBL12594251 | 0.82 | CYP3A4 (0.63) | CYP3A4CCR2CYP2C9NUDT1CYP2C19 | |
| SCHEMBL1762442 | 0.82 | CYP2C9 (0.64) | CYP3A4CCR2CYP2C9 | |
| SCHEMBL12594373 | 0.81 | CYP2C9 (0.55) | CYP3A4CCR2CYP2C9NUDT1AXL | |
| SCHEMBL1762314 | 0.80 | CYP2C9 (0.58) | CYP3A4CCR2CYP2C9NUDT1CYP2C19 | |
| SCHEMBL22461660 | 0.80 | CYP2C9 (0.65) | CYP3A4CCR2CYP2C9JAK1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4134080-A1 | CCR2 INHIBITORS FOR USE IN TREATING RENAL DISEASES | ChemoCentryx, Inc. (US) | 2023-02-15 | — | — | EP | disclosed |