SCHEMBL1762385

SCHEMBL1762385

Cc1cnc(C(=O)c2ccnc3[nH]ccc23)c(NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)c1

nearest known ligand 0.79

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.79
CCR2 P41597 14/20 0.78
CYP2C9 P11712 2/20 0.65
TSHR P16473 1/20 0.44
JAK1 P23458 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22461745 0.92 CYP3A4 (0.67) CYP3A4CCR2CYP2C9TSHRJAK1
SCHEMBL306637 0.92 CYP2C9 (0.77) CYP3A4CCR2CYP2C9TSHR
SCHEMBL22461660 0.90 CYP2C9 (0.65) CYP3A4CCR2CYP2C9TSHRJAK1
SCHEMBL12594251 0.90 CYP3A4 (0.63) CYP3A4CCR2CYP2C9
SCHEMBL25023972 0.89 CYP3A4 (0.64) CYP3A4CCR2CYP2C9TSHRJAK1
SCHEMBL1762398 0.89 CYP3A4 (0.63) CYP3A4CCR2CYP2C9TSHRJAK1
SCHEMBL170192 0.89 CYP3A4 (1.00) CYP3A4CCR2CYP2C9TSHR
SCHEMBL12594257 0.88 CCR2 (0.79) CYP3A4CCR2CYP2C9TSHRJAK1
Ilacirnon SCHEMBL127113 0.88 CCR2 (1.00) CYP3A4CCR2CYP2C9JAK1
Ilacirnon SCHEMBL31378455 0.88 CCR2 (1.00) CYP3A4CCR2CYP2C9JAK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8519135-B2 Heteroaryl sulfonamides and CCR2/CCR9 CHEMOCENTRYX, INC. (US) 2013-08-27 US claimed
EP-3463350-B1 PYRROLO-PYRIDINES AND PYRROLO-PYRIMIDINES FOR USE IN TREATING LIVER FIBROSIS CHEMOCENTRYX INC (US) 2023-09-13 EP disclosed
US-20230263784-A1 COMBINATION THERAPY USING A CHEMOKINE RECEPTOR 2 (CCR2) ANTAGONIST AND A PD-1/PD-L1 INHIBITOR CHEMOCENTRYX, INC. 2023-08-24 US disclosed
US-20230263784-A1 COMBINATION THERAPY USING A CHEMOKINE RECEPTOR 2 (CCR2) ANTAGONIST AND A PD-1/PD-L1 INHIBITOR CHEMOCENTRYX, INC. 2023-08-24 US disclosed
EP-4134080-A1 CCR2 INHIBITORS FOR USE IN TREATING RENAL DISEASES ChemoCentryx, Inc. (US) 2023-02-15 EP disclosed
US-11433061-B2 Heteroaryl sulfonamides and CCR2/CCR9 CHEMOCENTRYX, INC. (US) 2022-09-06 US disclosed
US-11433061-B2 Heteroaryl sulfonamides and CCR2/CCR9 CHEMOCENTRYX, INC. (US) 2022-09-06 US disclosed
US-11382915-B2 Treatment of focal segmental glomerulosclerosis with CCR2 antagonists CHEMOCENTRYX, INC. (US) 2022-07-12 US disclosed
US-11357760-B2 Method of treating liver fibrosis CHEMOCENTRYX, INC. (US) 2022-06-14 US disclosed
US-11324736-B2 Method of Treating Focal Segmental Glomerulosclerosis CHEMOCENTRYX, INC. (US) 2022-05-10 US disclosed
US-20140031348-A1 HETEROARYL SULFONAMIDES AND CCR2/CCR9 CHEMOCENTRYX INC (US) 2014-01-30 US disclosed
US-20140031348-A1 HETEROARYL SULFONAMIDES AND CCR2/CCR9 CHEMOCENTRYX INC (US) 2014-01-30 US disclosed
US-20140031348-A1 HETEROARYL SULFONAMIDES AND CCR2/CCR9 CHEMOCENTRYX INC (US) 2014-01-30 US disclosed
US-8519135-B2 Heteroaryl sulfonamides and CCR2/CCR9 CHEMOCENTRYX, INC. (US) 2013-08-27 US disclosed
US-8519135-B2 Heteroaryl sulfonamides and CCR2/CCR9 CHEMOCENTRYX, INC. (US) 2013-08-27 US disclosed
US-8519135-B2 Heteroaryl sulfonamides and CCR2/CCR9 CHEMOCENTRYX, INC. (US) 2013-08-27 US disclosed
US-20110118248-A1 Heteroaryl sulfonamides and CCR2/CCR9 CHEMOCENTRYX, INC. 2011-05-19 US disclosed
US-20110118248-A1 Heteroaryl sulfonamides and CCR2/CCR9 CHEMOCENTRYX, INC. 2011-05-19 US disclosed
US-20110118248-A1 Heteroaryl sulfonamides and CCR2/CCR9 CHEMOCENTRYX, INC. 2011-05-19 US disclosed
WO-2008008431-A2 HETEROARYL SULFONAMIDES AND CCR2/CCR9 CHEMOCENTRYX, INC. (US) 2008-01-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11433061-B2 Heteroaryl sulfonamides and CCR2/CCR9 CCR2, CCR9, CCR1 CYP3A4 1934/4885CCR2 1/4885CYP2C9 192/4885
US-11382915-B2 Treatment of focal segmental glomerulosclerosis with CCR2 antagonists REN, CCR2, AGTR2 CYP3A4 4759/4885CCR2 2/4885CYP2C9 4681/4885
US-20140031348-A1 HETEROARYL SULFONAMIDES AND CCR2/CCR9 CCR2, CCR9, CCR1 CYP3A4 1934/4885CCR2 1/4885CYP2C9 192/4885
US-20110118248-A1 Heteroaryl sulfonamides and CCR2/CCR9 CCR2, CCR9, CCR1 CYP3A4 1934/4885CCR2 1/4885CYP2C9 192/4885
US-11324736-B2 Method of Treating Focal Segmental Glomerulosclerosis SLC5A1, PTGFR, HPGDS CYP3A4 3325/4885CCR2 610/4885CYP2C9 2646/4885
US-20230263784-A1 COMBINATION THERAPY USING A CHEMOKINE RECEPTOR 2 (CCR2) ANTAGONIST AND A PD-1/PD-L1 INHIBITOR CCR2, PDCD1LG2, CD274 CYP3A4 3935/4885CCR2 1/4885CYP2C9 3501/4885
US-11357760-B2 Method of treating liver fibrosis CCR2, CMKLR2, CCL2 CYP3A4 1173/4885CCR2 1/4885CYP2C9 1921/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.