Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 15/20 | 0.53 |
| ▸ | IKZF3 | Q9UKT9 | 10/20 | 0.50 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.50 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | TNF | P01375 | 1/20 | 0.50 |
| ▸ | IL1B | P01584 | 1/20 | 0.50 |
| ▸ | MAP1LC3B | Q9GZQ8 | 5/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31753300 | 0.94 | CRBN (0.54) | CRBNIKZF3DDB1IKZF1BRD4 | |
| SCHEMBL30135733 | 0.91 | CRBN (0.58) | CRBNIKZF3DDB1IKZF1BRD4 | |
| SCHEMBL27099085 | 0.91 | CRBN (0.58) | CRBNIKZF3DDB1IKZF1BRD4 | |
| SCHEMBL31747465 | 0.88 | CRBN (0.55) | CRBNIKZF3DDB1IKZF1BRD4 | |
| SCHEMBL31752706 | 0.87 | CRBN (0.53) | CRBNIKZF3DDB1IKZF1BRD4 | |
| SCHEMBL31129754 | 0.86 | CRBN (0.52) | CRBNIKZF3DDB1IKZF1BRD4 | |
| SCHEMBL30936821 | 0.85 | CRBN (0.52) | CRBNIKZF3DDB1IKZF1BRD4 | |
| SCHEMBL19585510 | 0.84 | CRBN (0.54) | CRBNIKZF3DDB1IKZF1BRD4 | |
| SCHEMBL24474356 | 0.84 | CRBN (0.55) | CRBNIKZF3DDB1IKZF1TNF | |
| SCHEMBL23250121 | 0.84 | CRBN (0.50) | CRBNIKZF3DDB1IKZF1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023017446-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |
| WO-2023017442-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |