Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 13/20 | 0.40 |
| ▸ | JAK2 | O60674 | 11/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 6/20 | 0.39 |
| ▸ | TYK2 | P29597 | 4/20 | 0.39 |
| ▸ | BTK | Q06187 | 4/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.35 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PI4KA | P42356 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25035698 | 0.90 | LRRK2 (0.38) | JAK3JAK2LRRK2JAK1TYK2 | |
| SCHEMBL25035651 | 0.79 | JAK3 (0.32) | JAK3JAK2JAK1TYK2BTK | |
| SCHEMBL22343519 | 0.78 | JAK3 (0.41) | JAK3JAK2LRRK2JAK1TYK2 | |
| SCHEMBL25034420 | 0.78 | JAK2 (0.32) | JAK3JAK2JAK1TYK2BTK | |
| SCHEMBL25035696 | 0.75 | JAK2 (0.57) | JAK3JAK2LRRK2JAK1TYK2 | |
| SCHEMBL25035730 | 0.74 | LRRK2 (0.39) | JAK3JAK2LRRK2JAK1TYK2 | |
| SCHEMBL22343551 | 0.74 | LRRK2 (0.39) | JAK3JAK2LRRK2JAK1TYK2 | |
| SCHEMBL25035697 | 0.74 | JAK2 (0.32) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL25035644 | 0.69 | — | — | |
| SCHEMBL10315626 | 0.68 | JAK2 (0.59) | JAK3JAK2LRRK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023018954-A1 | TREATMENT OF JAK-INHIBITION-RESPONSIVE DISORDERS WITH PRODRUGS OF JAK INHIBITORS | CONCERT PHARMACEUTICALS, INC. (US) | 2023-02-16 | — | — | WO | disclosed |