Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 10/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31224595 | 1.00 | LMNA (0.49) | LMNAMAPTPOLBSMN1; SMN2RAB9A | |
| SCHEMBL25036318 | 0.88 | LMNA (0.48) | LMNAMAPTPOLBSMN1; SMN2RAB9A | |
| SCHEMBL30939032 | 0.88 | LMNA (0.48) | LMNAMAPTPOLBSMN1; SMN2RAB9A | |
| SCHEMBL30939039 | 0.86 | LMNA (0.47) | LMNAMAPTPOLBSMN1; SMN2RAB9A | |
| SCHEMBL25035747 | 0.86 | LMNA (0.47) | LMNAMAPTPOLBSMN1; SMN2RAB9A | |
| SCHEMBL25035746 | 0.86 | LMNA (0.50) | LMNAMAPTPOLBSMN1; SMN2RAB9A | |
| SCHEMBL30939048 | 0.86 | LMNA (0.50) | LMNAMAPTPOLBSMN1; SMN2RAB9A | |
| SCHEMBL25035748 | 0.83 | LMNA (0.48) | LMNAMAPTPOLBSMN1; SMN2RAB9A | |
| SCHEMBL25035740 | 0.83 | LMNA (0.48) | LMNAMAPTPOLBSMN1; SMN2RAB9A | |
| SCHEMBL25035745 | 0.83 | LMNA (0.52) | LMNAMAPTPOLBSMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023017154-A1 | [1,2,4]TRIAZOLO[4,3-A]PYRIMIDIN-7(8H)-ONE AS MITOCHONDRIAL PYRUVATE CARRIER INHIBITORS FOR USE IN THE TREATMENT OF CANCER | MPC THERAPEUTICS SA (CH) | 2023-02-16 | — | — | WO | disclosed |