Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HRH2 | P25021 | 2/20 | 0.36 |
| ▸ | HRH1 | P35367 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | GLS | O94925 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2503798 | 1.00 | AAK1 (0.38) | AAK1KMT2AMEN1ATMKDM4E | |
| SCHEMBL2508276 | 0.92 | PKM (0.40) | AAK1KMT2AMEN1ATMKDM4E | |
| SCHEMBL2508270 | 0.92 | PKM (0.40) | AAK1KMT2AMEN1ATMKDM4E | |
| SCHEMBL2507095 | 0.91 | AAK1 (0.37) | AAK1KMT2AMEN1ATMKDM4E | |
| SCHEMBL2507092 | 0.91 | AAK1 (0.37) | AAK1KMT2AMEN1ATMKDM4E | |
| SCHEMBL2506886 | 0.90 | KMT2A (0.41) | AAK1KMT2AMEN1ATMKDM4E | |
| SCHEMBL2505700 | 0.89 | KDM4E (0.42) | AAK1KMT2AMEN1ATMKDM4E | |
| SCHEMBL2505698 | 0.89 | KDM4E (0.42) | AAK1KMT2AMEN1ATMKDM4E | |
| SCHEMBL2507609 | 0.88 | AAK1 (0.42) | AAK1KMT2AKDM4EALDH1A1 | |
| SCHEMBL2507610 | 0.88 | AAK1 (0.42) | AAK1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8575183-B2 | Heterocyclic compounds and their uses | AMGEN INC. (US) | 2013-11-05 | — | — | US | disclosed |
| US-20110245257-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2011-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110245257-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | MCL1, BCL9, MALT1 | AAK1 836/4885KMT2A 829/4885MEN1 1636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.