Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.59 |
| ▸ | SIRT2 | Q8IXJ6 | 8/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.53 |
| ▸ | KDM4D | Q6B0I6 | 3/20 | 0.50 |
| ▸ | KDM6B | O15054 | 2/20 | 0.50 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | KDM4A | O75164 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | CDK7 | P50613 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL479807 | 0.87 | SIRT2 (0.54) | KDM4CSIRT2MAPK8SIRT1AURKA | |
| SCHEMBL2021338 | 0.87 | KDM4C (0.70) | KDM4CKDM4DKDM6BKDM4EKDM4A | |
| SCHEMBL2025681 | 0.84 | SIRT2 (0.49) | KDM4CSIRT2MAPK8KDM4DKDM6B | |
| SCHEMBL15286534 | 0.83 | KDM4C (0.57) | KDM4CSIRT2MAPK8KDM4DKDM6B | |
| SCHEMBL29867895 | 0.81 | MAPT (0.67) | KDM4CKDM4DAURKAKDM4EPTGS1 | |
| SCHEMBL2023347 | 0.81 | MAPT (0.67) | KDM4CKDM4DAURKAKDM4EPTGS1 | |
| SCHEMBL15286436 | 0.80 | KDM4C (0.54) | KDM4CSIRT2MAPK8KDM4DKDM6B | |
| SCHEMBL460199 | 0.80 | SIRT2 (0.62) | SIRT2MAPK8SIRT1AURKAJAK2 | |
| Anilinobenzamide SCHEMBL1318994 | 0.79 | SIRT2 (0.73) | SIRT2MAPK8SIRT1AURKA | |
| SCHEMBL15286451 | 0.79 | KDM4C (0.53) | KDM4CSIRT2KDM4DKDM6BAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307376-B1 | NOVEL PHENYLAMINO ISONICOTINAMIDE COMPOUNDS | MERCK PATENT GMBH (DE) | 2015-11-04 | — | — | EP | disclosed |
| US-8889719-B2 | Phenylamino isonicotinamide compounds | MERCK PATENT GMBH (DE) | 2014-11-18 | — | — | US | disclosed |
| US-8889719-B2 | Phenylamino isonicotinamide compounds | MERCK PATENT GMBH (DE) | 2014-11-18 | — | — | US | disclosed |
| CN-102099336-B | Phenylaminoisonicotinamide compounds | MERCK SERONO SA | 2013-11-06 | — | — | CN | disclosed |
| US-20130184314-A1 | Novel Phenylamino Isonicotinamide Compounds | MERCK PATENT GMBH (DE) | 2013-07-18 | — | — | US | disclosed |
| US-20130184314-A1 | Novel Phenylamino Isonicotinamide Compounds | MERCK PATENT GMBH (DE) | 2013-07-18 | — | — | US | disclosed |
| EP-2588452-A1 | METHOD FOR THE PREPARATION OF CIS-1,2-DIOLS IN THE KILOGRAM SCALE | Merck Patent GmbH (DE) | 2013-05-08 | — | — | EP | disclosed |
| US-20130102640-A1 | METHOD FOR THE PREPARATION OF CIS-1,2-DIOLS IN THE KILOGRAM SCALE | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-04-25 | — | — | US | disclosed |
| US-8404725-B2 | Phenylamino isonicotinamide compounds | MERCK PATENT GMBH (DE) | 2013-03-26 | — | — | US | disclosed |
| US-8404725-B2 | Phenylamino isonicotinamide compounds | MERCK PATENT GMBH (DE) | 2013-03-26 | — | — | US | disclosed |
| US-8404725-B2 | Phenylamino isonicotinamide compounds | MERCK PATENT GMBH (DE) | 2013-03-26 | — | — | US | disclosed |
| WO-2012000598-A1 | METHOD FOR THE PREPARATION OF CIS-1,2-DIOLS IN THE KILOGRAM SCALE | MERCK PATENT GMBH (DE) | 2012-01-05 | — | — | WO | disclosed |
| US-20110184032-A1 | Novel Phenylamino Isonicotinamide Compounds | MERCK PATENT GMBH (DE) | 2011-07-28 | — | — | US | disclosed |
| US-20110184032-A1 | Novel Phenylamino Isonicotinamide Compounds | MERCK PATENT GMBH (DE) | 2011-07-28 | — | — | US | disclosed |
| CN-102099336-A | Novel phenylamino isonicotinamide compounds | MERCK SERONO SA | 2011-06-15 | — | — | CN | disclosed |
| EP-2307376-A1 | NOVEL PHENYLAMINO ISONICOTINAMIDE COMPOUNDS | Merck Patent GmbH (DE) | 2011-04-13 | — | — | EP | disclosed |
| WO-2010017051-A1 | NOVEL PHENYLAMINO ISONICOTINAMIDE COMPOUNDS | MERCK SERONO S.A. (CH) | 2010-02-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110184032-A1 | Novel Phenylamino Isonicotinamide Compounds | MKI67, FGFR1, IGF1R | KDM4C 3239/4885SIRT2 263/4885MAPK8 551/4885 |
| US-20130102640-A1 | METHOD FOR THE PREPARATION OF CIS-1,2-DIOLS IN THE KILOGRAM SCALE | ADH1C, DEGS1, MAN1B1 | KDM4C 3800/4885SIRT2 1872/4885MAPK8 3887/4885 |
| US-20130184314-A1 | Novel Phenylamino Isonicotinamide Compounds | MKI67, FGFR1, IGF1R | KDM4C 3239/4885SIRT2 263/4885MAPK8 551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.