Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | STK3 | Q13188 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27607376 | 1.00 | HRH3 (0.37) | HRH3SLC6A2STK3LRRK2ACKR3 | |
| SCHEMBL23592559 | 0.83 | NCF1 (0.32) | — | |
| Thiocyanic Acid SCHEMBL26110665 | 0.78 | HRH3 (0.35) | HRH3SLC6A2LRRK2ACKR3 | |
| SCHEMBL25111815 | 0.78 | — | — | |
| SCHEMBL15038206 | 0.78 | — | — | |
| SCHEMBL25111482 | 0.78 | — | — | |
| SCHEMBL9936731 | 0.77 | HRH3 (0.41) | HRH3SLC6A2ACKR3 | |
| SCHEMBL9935790 | 0.77 | HRH3 (0.41) | HRH3SLC6A2ACKR3 | |
| SCHEMBL22811403 | 0.77 | HRH3 (0.35) | HRH3SLC6A2ACKR3 | |
| SCHEMBL1753592 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023018809-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2023-02-16 | — | — | WO | disclosed |