Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 9/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 6/20 | 0.36 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.35 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25048329 | 0.97 | PRMT5 (0.40) | PRMT5WDR77PIP4K2AMETTL3NPC1 | |
| SCHEMBL25048261 | 0.91 | IGF1R (0.36) | PRMT5WDR77PIP4K2AMETTL3 | |
| SCHEMBL25046638 | 0.91 | PRMT5 (0.38) | PRMT5WDR77PIP4K2AMETTL3 | |
| SCHEMBL25047713 | 0.90 | PRMT5 (0.41) | PRMT5WDR77PIP4K2AMETTL3ADORA2A | |
| SCHEMBL25048325 | 0.90 | PRMT5 (0.37) | PRMT5WDR77PIP4K2AMETTL3JAK2 | |
| SCHEMBL25048878 | 0.87 | EPHX2 (0.38) | PRMT5ALDH1A1MEN1KMT2A | |
| SCHEMBL25046802 | 0.83 | PRMT5 (0.54) | PRMT5WDR77METTL3 | |
| SCHEMBL25047776 | 0.82 | PRMT5 (0.54) | PRMT5WDR77METTL3 | |
| SCHEMBL25046637 | 0.81 | PRMT5 (0.39) | PRMT5WDR77PIP4K2AYTHDC1ADORA1 | |
| SCHEMBL31618052 | 0.80 | PRMT5 (0.55) | PRMT5WDR77METTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023017152-A1 | SPECIFIC SMALL MOLECULE INHIBITORS THAT BLOCK KMT9 METHYLTRANSFERASE ACTIVITY AND FUNCTION | ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG (DE) | 2023-02-16 | — | — | WO | disclosed |