⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11757886 | 0.91 | KDM4E (0.67) | — | |
| SCHEMBL28810976 | 0.91 | KDM4E (0.67) | — | |
| SCHEMBL48475 | 0.86 | — | — | |
| SCHEMBL1681786 | 0.79 | KDM4E (0.35) | — | |
| SCHEMBL293573 | 0.79 | — | — | |
| SCHEMBL21680768 | 0.79 | — | — | |
| SCHEMBL1519900 | 0.79 | — | — | |
| SCHEMBL19176934 | 0.78 | MEN1 (0.64) | — | |
| SCHEMBL20220922 | 0.77 | — | — | |
| SCHEMBL9058741 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023016529-A1 | NAPHTHYRIDINE DERIVATIVE AS ATR INHIBITOR AND METHOD FOR PREPARING SAME | 微境生物医药科技(上海)有限公司 | 2023-02-16 | — | — | WO | disclosed |
| CN-1065744-C | Treatment of diseases associated with platelet derived growth factor such as cancer | SUGEN INC (US) | 2001-05-16 | — | — | CN | disclosed |
| CN-1128496-A | Treatment of platelet derived growth factor related disorders such as cancers using inhibitors of platelet derived growth receptor | SUGEN INC (US) | 1996-08-07 | — | — | CN | disclosed |